cagrilintide semaglutide
Sponsors
Novo Nordisk A/S
Conditions
ObesityObesity and T2DOverweight and obesity and type 2 diabetesParticipants with obesity with or without type 2 diabetesType 2 DiabetesType 2 diabetes and painful diabetic peripheral neuropathyalcohol-related liver disease
Phase 2
Effects of NNC0194-0499 alone and in combination with semaglutide, of semaglutide alone, and of cagrilintide alone and in combination with semaglutide on liver damage and alcohol use in people with alcohol-related liver disease
CompletedCTIS2023-508170-28-00
Start: 2024-08-07End: 2026-01-12Target: 140Updated: 2025-12-18
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) once weekly versus placebo in participants with type 2 diabetes and painful diabetic peripheral neuropathy
Active, not recruitingCTIS2023-509662-38-00
Start: 2025-01-22Target: 55Updated: 2025-11-07
Phase 3
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c. 1.0 mg/1.0 mg and 1.7 mg/1.7 mg) once-weekly in participants with overweight or obesity
Active, not recruitingCTIS2023-509273-24-00
Start: 2024-09-05Target: 100Updated: 2025-09-17
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c.) once-weekly in participants with overweight or obesity and type 2 diabetes
CompletedCTIS2023-506931-13-00
Start: 2023-01-30End: 2025-01-28Target: 422Updated: 2025-09-19
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg/1.0 mg s.c. once weekly versus tirzepatide 5 mg s.c. once weekly in participants with type 2 diabetes inadequately controlled on metformin, SGLT2 inhibitor or both
RecruitingCTIS2023-509600-15-00
Start: 2024-10-18Target: 410Updated: 2025-11-10
Long-term efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema 2.4 mg/2.4 mg) once weekly versus placebo in participants with obesity
Active, not recruitingCTIS2024-512144-39-00
Start: 2025-01-22Target: 160Updated: 2025-11-14
Efficacy, safety and pharmacokinetics of cagrilintide s.c. 2.4 mg as monotherapy
and in combination with semaglutide s.c. 2.4 mg (CagriSema) once weekly for weight management
in children and adolescents with overweight or obesity
Not yet recruitingCTIS2023-509176-42-00
Target: 61Updated: 2026-04-29
A clinical study to compare efficacy and safety of two different doses of CagriSema and semaglutide in participants with obesity with or without type 2 diabetes
Not yet recruitingCTIS2025-522488-14-00
Target: 403Updated: 2026-07-28