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cagrilintide semaglutide

DRUG8 trials

Sponsors

Novo Nordisk A/S

Conditions

ObesityObesity and T2DOverweight and obesity and type 2 diabetesParticipants with obesity with or without type 2 diabetesType 2 DiabetesType 2 diabetes and painful diabetic peripheral neuropathyalcohol-related liver disease

Phase 2

Phase 3

Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c. 1.0 mg/1.0 mg and 1.7 mg/1.7 mg) once-weekly in participants with overweight or obesity
Active, not recruitingCTIS2023-509273-24-00
Novo Nordisk A/SObesity
Start: 2024-09-05Target: 100Updated: 2025-09-17
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c.) once-weekly in participants with overweight or obesity and type 2 diabetes
CompletedCTIS2023-506931-13-00
Novo Nordisk A/SOverweight and obesity and type 2 diabetes
Start: 2023-01-30End: 2025-01-28Target: 422Updated: 2025-09-19
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg/1.0 mg s.c. once weekly versus tirzepatide 5 mg s.c. once weekly in participants with type 2 diabetes inadequately controlled on metformin, SGLT2 inhibitor or both
RecruitingCTIS2023-509600-15-00
Novo Nordisk A/SType 2 Diabetes
Start: 2024-10-18Target: 410Updated: 2025-11-10
Long-term efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema 2.4 mg/2.4 mg) once weekly versus placebo in participants with obesity
Active, not recruitingCTIS2024-512144-39-00
Novo Nordisk A/SObesity
Start: 2025-01-22Target: 160Updated: 2025-11-14
Efficacy, safety and pharmacokinetics of cagrilintide s.c. 2.4 mg as monotherapy and in combination with semaglutide s.c. 2.4 mg (CagriSema) once weekly for weight management in children and adolescents with overweight or obesity
Not yet recruitingCTIS2023-509176-42-00
Novo Nordisk A/SObesity and T2D
Target: 61Updated: 2026-04-29
A clinical study to compare efficacy and safety of two different doses of CagriSema and semaglutide in participants with obesity with or without type 2 diabetes
Not yet recruitingCTIS2025-522488-14-00
Novo Nordisk A/SParticipants with obesity with or without type 2 diabetes
Target: 403Updated: 2026-07-28