BIA 5-1058

Safety, Tolerability, Pharmacokinetic, Including Food Interaction, and Pharmacodynamic Profile of BIA 5-1058.

Effect of BIA 5 1058 on Cardiac Repolarization

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIA 5-1058

Effect of BIA 5-1058 on the Steady State Pharmacokinetics of Treprostinil

Effect of Age-gender on the Pharmacokinetic and Pharmacodynamic Profiles of BIA 5 1058

Effect of Food on BIA 5-1058

Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Bosentan

Effect of BIA 5-1058 400 mg on Warfarin Pharmacokinetics

Effect of BIA 5-1058 400 mg on the Steady State Pharmacokinetics of Sildenafil

Pharmacokinetics, Safety and Tolerability of Concurrent Doses of BIA 5-1058 and Furosemide

An open-label study to assess the absorption, distribution, metabolism and excretion, including the mass balance of [14C] labeled BIA 5-1058 and metabolites following a single oral dose administration in healthy male subjects