Belumosudil
Sponsors
Sanofi-Aventis Recherche & Developpement, Kadmon Corporation, LLC, Sanofi, Kadmon, a Sanofi Company, Dana-Farber Cancer Institute
Conditions
Autoimmune DiseasesBronchiolitis ObliteransBronchiolitis Obliterans SyndromeChronic Graft Versus Host DiseaseChronic Plaque PsoriasisChronic graft versus host disease.Diffuse Cutaneous Systemic SclerosisDrug-drug Interaction
Phase 1
Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers
CompletedNCT03530995
Start: 2018-04-09End: 2019-02-08Updated: 2022-05-25
Isatuximab in Combination With Novel Agents in RRMM - Master Protocol
RecruitingNCT04643002
Start: 2021-01-25End: 2028-04-20Target: 258Updated: 2026-03-30
A Study to Assess the Effect of Oral Belumosudil on Inhibition of Various Proteins in the Fed State in Healthy Male Subjects
CompletedNCT05806567
Start: 2022-07-27End: 2022-10-28Updated: 2025-09-25
An open-label, Phase 1/2, multicenter study of belumosudil in children aged 1 to <18 years requiring systemic treatment for active moderate-to-severe chronic graft versus host disease (cGVHD).
RecruitingCTIS2024-511508-18-00
Start: 2026-01-05Target: 23Updated: 2025-11-26
IL6-receptor Inhibitor Iwith Belumosudil for the Treatment of Belumosudil-refractory cGVHD
Not yet recruitingNCT07484113
Start: 2026-05-01End: 2028-05-01Target: 10Updated: 2026-03-19
Phase 2
A Safety and Tolerability Study of Belumosudil (KD025) Treatment in Subjects With Moderately Severe Psoriasis Vulgaris
CompletedNCT02106195
Start: 2014-04-30End: 2014-09-30Updated: 2022-03-23
A 2-Part, Phase 2 Open-label and Crossover Study of Belumosudil for Treatment of Idiopathic Pulmonary Fibrosis
CompletedNCT02688647
Start: 2016-05-26End: 2021-04-13Updated: 2022-09-08
A Phase 2, Double-blind, Placebo-controlled Study of the Efficacy and Safety of Belumosudil in Subjects With Moderate/Severe Chronic Plaque Psoriasis
CompletedNCT02852967
Start: 2016-09-14End: 2019-02-13Updated: 2022-03-16
Efficacy and Safety of Belumosudil in Subjects With Diffuse Cutaneous Systemic Sclerosis
TerminatedNCT04680975
Start: 2021-03-03End: 2022-12-19Updated: 2023-06-05
Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy
WithdrawnNCT05567406
Start: 2025-06-16End: 2026-08-31Updated: 2026-02-12
BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)
RecruitingNCT05922761
Start: 2024-05-31End: 2027-12-31Target: 45Updated: 2026-02-11
Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease
RecruitingNCT05996627
Start: 2023-12-06End: 2028-11-30Target: 82Updated: 2026-02-17
Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease
RecruitingNCT06046248
Start: 2024-01-29End: 2027-12-31Target: 25Updated: 2025-10-30
Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients
RecruitingNCT06476132
Start: 2025-03-12End: 2027-06-30Target: 234Updated: 2026-01-20
A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant
RecruitingNCT07006506
Start: 2025-05-21End: 2029-05-21Target: 46Updated: 2026-03-24
A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)
RecruitingNCT07116031
Start: 2025-12-02End: 2031-02-28Target: 37Updated: 2026-02-27
Phase 3
A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
RecruitingNCT06082037
Start: 2023-10-10End: 2030-10-01Target: 180Updated: 2026-03-25
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
Active, not recruitingNCT06143891
Start: 2024-01-23End: 2028-09-29Target: 260Updated: 2025-10-14
Phase 4
A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies
Active, not recruitingNCT06616415
Start: 2024-12-04End: 2026-05-13Updated: 2025-06-22
A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD)
Not yet recruitingNCT07135973
Start: 2026-04-15End: 2028-03-17Target: 26Updated: 2026-03-03