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Aztreonam-Avibactam

DRUG5 trials

Sponsors

Pfizer, French Society for Intensive Care, Sir Run Run Shaw Hospital, IRCCS Azienda Ospedaliero-Universitaria di Bologna

Conditions

Antibiotic ResistanceCRE ColonizationCarbapenem-resistant EnterobacteralesComplicated Intra-Abdominal Infections, cIAIsCritical CareHealthyHospital-acquired Pneumonia (HAP)Infection

Phase 1

Pharmacokinetic Study of Aztreonam-Avibactam in Severe Renal Impairment
CompletedNCT04486625
PfizerRenal Insufficiency
Start: 2020-08-10End: 2021-10-18Updated: 2023-07-28
Study to Assess the Pharmacokinetics, Safety and Tolerability of Aztreonam-Avibactam in Healthy Chinese Participants.
CompletedNCT04973826
PfizerHealthy
Start: 2021-08-20End: 2021-09-27Updated: 2023-07-28

Phase 3

Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation
Not yet recruitingNCT07759453
IRCCS Azienda Ospedaliero-Universitaria di BolognaLiver Transplant, Carbapenem-resistant Enterobacterales, CRE Colonization
Start: 2026-10-01End: 2029-09-30Target: 168Updated: 2026-08-12

Unknown Phase

Real-world Multicentre Study of AZtreonam-AVIbactam Treatment With Infections or Suspected Infections Caused by Multidrug-resistant Gram-negative Bacteria
Enrolling by invitationNCT07176247
French Society for Intensive CareCritical Care, Infection, Antibiotic Resistance +1
Start: 2024-01-01End: 2028-12-31Target: 100Updated: 2025-09-16
Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRE
RecruitingNCT07268560
Sir Run Run Shaw HospitalComplicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Start: 2025-12-25End: 2027-07-31Target: 100Updated: 2026-03-23