AZD6234
Sponsors
AstraZeneca AB, AstraZeneca
Conditions
Diabetes, Type IIEndocrinologyHealthy ParticipantsInvestigating obesity or overweight condition correlated to many co-morbiditiesObesityObesity or OverweightObesity/OverweightOverweight and obesity
Phase 1
Assess the Safety, Tolerability, and Pharmacokinetics of AZD6234 Following Single Ascending Dose Administration to Healthy Subjects Who Are Overweight or Obese
CompletedNCT05511025
Start: 2022-09-20End: 2023-12-19Updated: 2023-12-26
A Phase I/II, Randomised, Single-blind, Placebo-controlled, Multiple-ascending-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD9550 Monotherapy and Co-administration of AZD9550 and AZD6234 in Participants Living with Obesity and Overweight with or without Type 2 Diabetes Mellitus
Active, not recruitingCTIS2023-504215-32-00
Start: 2023-09-28Target: 101Updated: 2025-10-15
A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD6234 After Repeat Dose Administration in Participants Who Are Overweight or Obese
CompletedNCT06132841
Start: 2023-11-13End: 2026-03-07Updated: 2026-04-03
Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD6234
CompletedNCT06845813
Start: 2025-02-24End: 2025-09-30Updated: 2025-11-03
A Study to Investigate the Effect of AZD6234, AZD9550, and a Combination of AZD9550 and AZD6234 on Pharmacokinetics of Combined Oral Contraceptive Ethinyl Estradiol/Levonorgestrel in Healthy Female Participants Living With Overweight or Obesity
RecruitingNCT07013643
Start: 2025-06-04End: 2026-12-25Target: 75Updated: 2026-03-03
Phase 2
A Study in Participants With Obesity or Overweight With at Least One Weight-related Comorbidity
CompletedNCT06595238
Start: 2024-10-01End: 2025-12-03Updated: 2025-12-17
A Phase IIb Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety and Tolerability of Co-administration of AZD9550 and AZD6234 in Participants Living With Obesity or
Overweight with Comorbidity
Active, not recruitingCTIS2024-516176-15-00
Start: 2025-02-24Target: 40Updated: 2025-12-22
Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on a Stable Dose of GLP-1 Receptor Agonist
Active, not recruitingNCT06851858
Start: 2025-03-12End: 2026-05-27Updated: 2026-03-03
A Weight Loss Study Evaluating Subcutaneous Treatment With AZD9550 and AZD6234 in Combination Against Placebo or Each of the Drugs Alone
Active, not recruitingNCT06862791
Start: 2025-02-18End: 2026-05-25Updated: 2026-02-02
This is a Multi-centre, Multi-drug, Platform Study in Chinese Participants Living With Obesity / Overweight
RecruitingNCT07017179
Start: 2025-05-20End: 2026-08-06Target: 871Updated: 2026-01-27