AZD0486
Sponsors
Astrazeneca AB, AstraZeneca AB, AstraZeneca
Conditions
Antibody-mediated Kidney DiseaseB-Cell Acute Lymphoblastic LeukaemiaB-cell Acute Lymphoblastic Leukemia (B-ALL)Chronic Lymphocytic LeukaemiaLarge B-Cell LymphomaLarge B-cell LymphomaMantle Cell LymphomaRelapsed or Refractory Non-Hodgkin Lymphoma
Phase 1
AZD0486 as Monotherapy in B-cell Acute Lymphoblastic Leukaemia
RecruitingNCT06137118
Start: 2023-12-29End: 2027-06-29Target: 236Updated: 2026-05-27
A Phase 1/2 Study to Evaluate the Safety and Efficacy of AZD0486 in Adolescent and Adult Participants with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia
RecruitingCTIS2023-505840-20-00
Start: 2024-08-16Target: 69Updated: 2026-01-22
A Phase I/II Open-Label Multi-Centre Master Protocol to Evaluate the Safety and Efficacy of AZD0486 Monotherapy or in Combination with Other Anticancer Agents in Participants with Mature B-Cell Malignancies
Substudy 1: Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphoma
Substudy 2: Mantle Cell Lymphoma
Substudy 3: Large B-Cell Lymphoma
RecruitingCTIS2024-515034-33-00
Start: 2025-03-05Target: 200Updated: 2025-11-25
Phase 2
A Modular Phase II, Single-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Surovatamig (AZD0486) in Participants with Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (SOUNDTRACK-B) )
RecruitingCTIS2023-505789-27-00
Start: 2025-04-14Target: 73Updated: 2025-12-01
A Phase 2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Surovatamig in Adults with Antibody-mediated Kidney Disease
Not yet recruitingCTIS2025-524139-38-00
Target: 5Updated: 2026-07-15
Phase 3
AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL
RecruitingNCT07215585
Start: 2025-11-11End: 2033-07-28Target: 420Updated: 2026-06-18
A Phase III, Multicentre, Open-Label, Randomised Study Evaluating the Efficacy and Safety of R-mini-CHOP x2 followed by AZD0486 versus R-mini-CHOP x6 in Elderly or Unfit Participants with Newly Diagnosed Large B-cell Lymphoma (SOUNDTRACK-D2)
Not yet recruitingCTIS2025-522029-37-00
Target: 14Updated: 2026-01-30