Atacicept
Sponsors
Vera Therapeutics Inc., EMD Serono, Merck KGaA, Darmstadt, Germany, Vera Therapeutics, Inc., Merck BV - An affiliate of Merck Serono S.A.
Conditions
Berger DiseaseFSGSIgA NephropathyIgA Nephropathy (IgAN)IgA Nephropathy (IgAN); Berger Disease; Renal and Urinary DisordersIgANLupus NephritisLupus Nephritis (LN)
Phase 1
Phase 2
A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I)
CompletedNCT00430495
Start: 2006-12-31End: 2009-09-30Updated: 2016-02-17
The Efficacy and Safety of Atacicept in Combination With Mycophenolate Mofetil Used to Treat Lupus Nephritis
TerminatedNCT00573157
Start: 2007-12-31End: 2009-04-30Updated: 2016-03-23
Atacicept in Anti-Tumor Necrosis Factor Alpha-naïve Subjects With Rheumatoid Arthritis (AUGUST II)
CompletedNCT00595413
Start: 2007-09-30End: 2009-10-31Updated: 2016-02-17
Atacicept in Subjects With Optic Neuritis
TerminatedNCT00624468
Start: 2008-06-30End: 2011-01-31Updated: 2016-02-17
A Phase 2 Study of Atacicept in Subjects With Relapsing Multiple Sclerosis (ATAMS)
TerminatedNCT00642902
Start: 2008-04-30End: 2009-09-30Updated: 2016-05-24
Atacicept in Combination With Rituximab in Subjects With Rheumatoid Arthritis (August III)
CompletedNCT00664521
Start: 2008-03-31End: 2010-10-31Updated: 2016-12-30
Atacicept Demonstrating Dose RESponSe
WithdrawnNCT01440231
Start: 2012-02-29End: 2014-02-28Updated: 2013-08-21
A Phase 2b/3, Multi-part, Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Atacicept in Subjects with IgA Nephropathy (IgAN)
Active, not recruitingCTIS2023-503772-24-00
Start: 2021-09-15Target: 216Updated: 2025-11-18
A Multicenter, Rollover Study to Evaluate the Long-Term Safety and Efficacy of Atacicept
RecruitingCTIS2024-516380-81-00
Start: 2025-02-28Target: 23Updated: 2025-11-18
Atacicept in Multiple Glomerular Diseases
RecruitingNCT06983028
Start: 2025-07-07End: 2027-11-01Target: 250Updated: 2026-06-26
Monthly Dosing of Atacicept in IgAN
Active, not recruitingNCT07020923
Start: 2025-05-29End: 2027-09-01Target: 90Updated: 2026-04-13
A Phase 2 Study to Evaluate the Safety and Efficacy of Atacicept in Multiple Autoimmune Glomerular Diseases (PIONEER)
RecruitingCTIS2024-518465-10-00
Start: 2025-12-12Target: 107Updated: 2025-12-04
A Study Evaluating Monthly (Every 4 Weeks) Dosing of Atacicept in Patients with IgAN
RecruitingCTIS2025-521519-37-00
Start: 2025-10-10Target: 27Updated: 2025-09-27
Phase 3
A randomised, double-blind, placebo-controlled,
multicentre prospective dose-finding Phase II/III study
with atacicept given subcutaneously to subjects having
recently experienced a flare of systemic lupus
erythematosus (SLE)
Active, not recruitingNL-OMON39295
Start: 2008-06-16Target: 34Updated: 2024-02-28
Atacicept in Subjects With IgA Nephropathy
Active, not recruitingNCT04716231
Start: 2023-06-29End: 2028-07-31Target: 376Updated: 2025-09-30
Atacicept in Subjects With Active Lupus Nephritis (COMPASS)
WithdrawnNCT05609812
Start: 2022-11-02End: 2028-12-15Updated: 2025-05-23