Aortic valve intervention

PROCEDURE2 trials

Sponsors

University of Edinburgh, University College, London

Conditions

Aortic Valve StenosisHypertrophy, Left VentricularValvular Heart Disease

Unknown Phase

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS

Active, not recruitingNCT03094143

University of EdinburghAortic Valve Stenosis, Hypertrophy, Left Ventricular

Start: 2017-07-21End: 2032-06-30Target: 1000Updated: 2026-09-10

Pathological Changes in the Cardiovascular System in Valvular Heart Disease

University College, LondonValvular Heart Disease

Start: 2021-08-01End: 2025-01-01Target: 360Updated: 2023-10-06

Related Papers

Myocardial Fibrosis and Early Intervention in Asymptomatic Patients With Severe Aortic Stenosis: Insights From the EVOLVED Randomized Clinical Trial.

2026-04-15

Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.

2025-01-0161 citations

Regional Distribution of Extracellular Volume Quantified by Cardiac CT in Aortic Stenosis: Insights Into Disease Mechanisms and Impact on Outcomes

Circulation Cardiovascular Imaging2024-05-0114 citations

Optimal treatment of asymptomatic patients with severe aortic stenosis: protocol of a prospective, multicentre, registry study

BMJ Open2023-12-011 citations

Treatment in patients with severe asymptomatic aortic stenosis: is it best not to wait?

European Heart Journal Supplements2022-11-123 citations

Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions.

2020-07-2220 citations

Progression of Hypertrophy and Myocardial Fibrosis in Aortic Stenosis

Circulation Cardiovascular Imaging2018-06-01185 citations