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Antidepressant + Placebo

DRUG6 trials

Sponsors

Otsuka Pharmaceutical Development & Commercialization, Inc., Bristol-Myers Squibb, Forest Laboratories, Shire

Conditions

Major Depressive Disorder

Phase 2

Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder
CompletedNCT00854100
Forest LaboratoriesMajor Depressive Disorder
Start: 2009-06-30End: 2010-12-06Updated: 2019-03-05
Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant
CompletedNCT00905424
ShireMajor Depressive Disorder
Start: 2009-07-30End: 2010-08-04Updated: 2021-06-14
SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
CompletedNCT01435759
ShireMajor Depressive Disorder
Start: 2011-05-31End: 2014-01-17Updated: 2021-06-09

Phase 3

A Study of Adjunctive Aripiprazole in Patients With Major Depressive Disorder
CompletedNCT00095823
Bristol-Myers SquibbMajor Depressive Disorder
Start: 2004-06-30End: 2006-08-31Target: 1200Updated: 2013-11-25
A Study of Adjunctive Aripiprazole in Participants With Major Depressive Disorder
CompletedNCT00095758
Otsuka Pharmaceutical Development & Commercialization, Inc.Major Depressive Disorder
Start: 2004-09-01End: 2006-12-01Updated: 2026-07-13
Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder
CompletedNCT01436162
ShireMajor Depressive Disorder
Start: 2011-10-19End: 2013-12-10Updated: 2021-06-09

Related Papers

Safety and Tolerability of Cariprazine for the Adjunctive Treatment of Major Depressive Disorder: A Pooled Analysis of Phase 2B and 3 Clinical Trials
CNS Spectrums2023-04-011 citations
Efficacy of adjunctive low-dose cariprazine in major depressive disorder
International Clinical Psychopharmacology2018-07-2556 citations
Effect of symptom severity on efficacy and safety of aripiprazole adjunctive to antidepressant monotherapy in major depressive disorder: A pooled analysis
Journal of Affective Disorders2014-03-2416 citations
A Randomized Controlled Trial of the Efficacy and Safety of Lisdexamfetamine Dimesylate as Augmentation Therapy in Adults With Residual Symptoms of Major Depressive Disorder After Treatment With Escitalopram
The Journal of Clinical Psychiatry2013-08-1555 citations
Improvement in functional outcomes with adjunctive aripiprazole versus placebo in major depressive disorder: a pooled post hoc analysis of 3 short-term studies.
2012-12-203 citations
Beneficial effects of adjunctive aripiprazole in major depressive disorder are not dependent on antidepressant therapy history: a post hoc analysis of 3 randomized, double-blind, placebo-controlled trials.
2012-11-222 citations
Efficacy of adjunctive aripiprazole in major depressive disorder: a pooled response quartile analysis and the predictive value of week 2 early response.
2012-05-314 citations
Effects of adjunctive aripiprazole on sexual functioning in patients with major depressive disorder and an inadequate response to standard antidepressant monotherapy: a post hoc analysis of 3 randomized, double-blind, placebo-controlled studies.
2011-01-0111 citations
Analysis of suicidality in pooled data from 2 double-blind, placebo-controlled aripiprazole adjunctive therapy trials in major depressive disorder.
2010-08-247 citations
Safety and Tolerability of Adjunctive Aripiprazole in Major Depressive Disorder: A Pooled Post Hoc Analysis (studies CN138-139 and CN138-163).
2009-01-0118 citations
Adjunctive aripiprazole in major depressive disorder: analysis of efficacy and safety in patients with anxious and atypical features.
2008-12-0236 citations
Examining the efficacy of adjunctive aripiprazole in major depressive disorder: a pooled analysis of 2 studies.
2008-01-0130 citations
The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study.
2007-06-01259 citations