Amifostine

DRUG20 trials

Sponsors

Jonsson Comprehensive Cancer Center, Dana-Farber Cancer Institute, M.D. Anderson Cancer Center, MedImmune LLC, University of Alabama at Birmingham

Conditions

Bladder CancerBrain TumorsBrain and Central Nervous System TumorsBreast CancerCancer of Head and NeckCarcinoma of Unknown PrimaryCervical CancerChemotherapeutic Agent Toxicity

Phase 1

Phase I Study of Amifostine in Patients With Bone Marrow Failure Related to Fanconi's Anemia

Dana-Farber Cancer InstituteFanconi's Anemia

Start: 2000-04-30Target: 21Updated: 2005-06-24

Radiation With Chemotherapy and a Study Drug to the Para-Aortic Nodes in Cervical Cancer

WithdrawnNCT00137358

University of Alabama at BirminghamCervical Cancer

Updated: 2013-01-24

Cisplatin and Docetaxel Plus Docetaxel and Radiotherapy With Amifostine for Squamous Cell Carcinoma of the Head and Neck

CompletedNCT00318890

University of Alabama at BirminghamCancer of Head and Neck, Head and Neck Cancer, Head Cancer +2

Start: 2002-10-31End: 2007-12-31Updated: 2019-02-05

Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma

CompletedNCT00571298

Brigham and Women's HospitalMalignant Pleural Mesothelioma

Start: 2007-11-30End: 2015-06-30Updated: 2017-01-23

Study of Cytoreductive Surgery and Hyperthermic Intrathoracic Pleural Chemotherapy (HITC) With Escalating Doses for Children and Adolescents With Unilateral Pleural Malignancy

CompletedNCT01998529

M.D. Anderson Cancer CenterLung Cancer

Start: 2014-08-20End: 2020-08-25Updated: 2023-09-14

Phase 2

Amifostine in Treating Peripheral Neuropathy Caused by Paclitaxel in Patients With Solid Tumors

CompletedNCT00078845

M.D. Anderson Cancer CenterBreast Cancer, Lung Cancer, Neurotoxicity +3

Start: 2004-05-31End: 2007-05-31Updated: 2012-10-17

High-dose ICE With Amifostine

CompletedNCT00003657

Dana-Farber Cancer InstituteBladder Cancer, Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary +8

Start: 1998-07-31End: 2002-06-30Updated: 2017-01-20

Subcutaneous Amifostine (Ethyol®) in the Prevention of Radiochemotherapy-Induced Esophagitis and Pneumonitis in Patients With Unresectable Non-Small Cell Lung Cancer

CompletedNCT00081315

MedImmune LLCEsophagitis, Non-Small Cell Lung Carcinoma, Pneumonitis

Start: 2003-11-30End: 2006-08-31Target: 130Updated: 2007-08-21

Combination Chemotherapy With or Without Amifostine in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Hodgkin's Disease Undergoing Stem Cell Transplantation

CompletedNCT00003143

Jonsson Comprehensive Cancer CenterLymphoma

Start: 1997-11-30Updated: 2012-10-04

Randomized Amifostine For SCCHN

CompletedNCT00095927

Dana-Farber Cancer InstituteChemotherapeutic Agent Toxicity, Head and Neck Cancer, Mucositis +2

Start: 2003-05-31End: 2008-06-30Updated: 2017-01-04

Amifostine for Head and Neck Irradiation in Lymphoma

CompletedNCT00136474

Dana-Farber Cancer InstituteHodgkin's Disease, Lymphoma, Non-Hodgkin's Lymphoma

Start: 2003-05-31End: 2009-03-31Target: 75Updated: 2009-11-02

EVALUATION OF AMIFOSTINE FOR MUCOSAL AND HEMOPOETIC PROTECTION AND CARBOPLATIN, TAXOL, RADIOTHERAPY IN THE MANAGEMENT OF PATIENTS WITH HEAD AND NECK CANCER.(GCC 0202)

CompletedNCT00270790

Mohan SuntharalingamHead and Neck Cancer

Start: 2002-05-31End: 2009-02-28Updated: 2017-02-01

Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment

TerminatedNCT00409331

M.D. Anderson Cancer CenterHead and Neck Cancer

Start: 2006-12-31End: 2009-01-31Updated: 2012-08-07

A Study of Amifostine (Ethyol) in Patients With Colorectal Cancer

TerminatedNCT00601198

University of CincinnatiColorectal Cancer

Start: 2006-10-31End: 2010-01-13Updated: 2023-08-01

A Phase II Study of Amifostine for the Prevention of Acute Radiation-Induced Rectal Toxicity

Chinese Academy of Medical SciencesRectal Cancer

Start: 2012-02-29End: 2014-12-31Target: 40Updated: 2013-08-15

Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer

Fudan UniversityLocally Advanced Rectal Cancer

Start: 2018-05-28End: 2020-03-01Target: 160Updated: 2019-01-23

High Dose Chemotherapy With Amifostine and Autologous Stem Cell Transplantation for High Risk Relapsed Pediatric Solid Tumors and Brain Tumors

TerminatedNCT05167370

Children's Hospital Medical Center, CincinnatiBrain Tumors, Solid Tumors

Start: 2010-12-13End: 2012-04-24Updated: 2022-01-25

Phase 3

Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer

CompletedNCT00274937

Children's Oncology GroupStage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage III Nasopharyngeal Undifferentiated Carcinoma AJCC v7, Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 +5

Start: 2006-02-20End: 2022-09-30Updated: 2022-10-25

A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia

TerminatedNCT01364259

Stanford UniversityTrigeminal Neuralgia

Start: 2008-09-30End: 2015-01-31Updated: 2017-04-04

Phase 4

Prospective Study of Head and Neck Cancer Radiation Treatment With or Without Amifostine

WithdrawnNCT01288625

Sun Pharmaceutical Industries LimitedOral Mucositis, Stomatitis

Updated: 2021-11-17

Related Papers

Treatment of childhood nasopharyngeal carcinoma (cNPC) with neoadjuvant chemotherapy (NAC) and concomitant chemoradiotherapy (CCRT): Results of the Children’s Oncology Group ARAR0331 study.

Journal of Clinical Oncology2016-05-2010 citations