alirocumab SAR236553 (REGN727)
Sponsors
Sanofi, Regeneron Pharmaceuticals
Conditions
HypercholesterolaemiaHypercholesterolemia
Phase 1
Injection Site Tolerability, Safety, Pharmacokinetics, Pharmacodynamics in Different Single-Dose Treatments of Alirocumab SAR236553 (REGN727) in Healthy Subjects
CompletedNCT01443650
Start: 2011-07-31End: 2011-11-30Updated: 2013-06-28
Study of the Tolerability, Safety, Pharmacokinetics and Pharmacodynamics of Alirocumab SAR236553 (REGN727)
CompletedNCT01448304
Start: 2011-06-30End: 2011-09-30Updated: 2013-06-28
Injection Site Tolerability, Safety, Pharmacokinetics and Pharmacodynamics Study After a Single Dose Subcutaneous Treatment of Alirocumab SAR236553 (REGN727)
CompletedNCT01448239
Start: 2011-02-28End: 2011-05-31Updated: 2013-06-28
Pharmacokinetic and Tolerability of Alirocumab SAR236553 (REGN727) in Patients With Hepatic Impairment and in Healthy Subjects
CompletedNCT01670734
Start: 2012-09-30End: 2013-05-31Updated: 2013-06-28
Pharmacokinetic of Alirocumab SAR236553 (REGN727) Administered Subcutaneously at 3 Different Injection Sites in Healthy Subjects
CompletedNCT01785329
Start: 2013-02-28End: 2013-07-31Updated: 2013-08-19
A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous (SC) Administered Alirocumab in Healthy Chinese Subjects
CompletedNCT02979015
Start: 2016-11-29End: 2017-11-27Updated: 2017-12-05
Phase 2
Phase 3
Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)
CompletedNCT02476006
Start: 2015-06-23End: 2019-04-12Updated: 2022-03-28
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia
CompletedNCT03510884
Start: 2018-05-31End: 2022-08-05Updated: 2023-05-06
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia
CompletedNCT03510715
Start: 2018-08-31End: 2020-02-17Updated: 2020-12-29