Adrenalectomy

PROCEDURE15 trials

Sponsors

Region Skane, National Cancer Institute (NCI), Vanderbilt University, Queen Mary University of London, Changi General Hospital

Conditions

Adrenal IncidentalomaAdrenal NeoplasmAdrenal TumorAdrenal Tumour With Mild HypercortisolismAdrenalectomyAppetite DisordersCardiovascular ComplicationCushing Syndrome

Phase 2

Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism

TerminatedNCT02001051

National Cancer Institute (NCI)Adrenal Neoplasm, Cushing Syndrome, Subclinical Hypercortisolism

Start: 2013-11-27End: 2018-02-26Updated: 2018-06-14

Phase 4

Metyrapone Versus Osilodrostat in Patients With Metabolic Autonomous Cortisol Secretion (MACS)

RecruitingNCT07268222

Laikο General Hospital, AthensMild Autonomous Cortisol Secretion (MACS)

Start: 2025-12-01End: 2027-11-25Target: 150Updated: 2025-12-05

Unknown Phase

Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

TerminatedNCT01246739

Region SkaneAdrenal Tumour With Mild Hypercortisolism

Start: 2011-06-30End: 2024-02-29Updated: 2024-04-10

Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

CompletedNCT02362308

Vanderbilt UniversityPrimary Aldosteronism

Start: 2015-01-31End: 2020-01-31Updated: 2021-05-04

IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism

CompletedNCT02945904

Queen Mary University of LondonHyperaldosteronism, Primary Aldosteronism

Start: 2016-12-01End: 2021-08-31Updated: 2025-03-10

Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism

CompletedNCT03174847

Changi General HospitalPrimary Aldosteronism, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Primary Aldosteronism Due to Aldosterone Producing Adenoma

Start: 2017-02-20End: 2020-09-20Updated: 2022-05-20

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations

RecruitingNCT04127552

University of Roma La SapienzaAdrenal Incidentaloma, Adrenal Tumor, Hypercortisolism

Start: 2019-01-02End: 2025-12-31Target: 68Updated: 2025-03-28

Investigating Salt Taste Threshold in Patients Being Investigated for Primary Hyperaldosteronism Before and After Treatment.

WithdrawnNCT04556279

Imperial College LondonAppetite Disorders, Hyperaldosteronism; Primary, Hypertension +1

Start: 2021-01-31End: 2022-03-31Updated: 2024-05-10

Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas

Fondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoAdrenal Incidentaloma, Subclinical Hypercortisolism

Start: 2016-09-29End: 2022-12-08Target: 61Updated: 2021-04-26

Textbook Outcome in Adrenal Neoplasms

CompletedNCT05888753

Hospital General Universitario de AlicanteAdrenal Neoplasm, Outcome Assessment

Start: 2022-09-01End: 2023-04-01Updated: 2023-06-22

Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma

CompletedNCT06062082

Central Hospital, Nancy, FranceNon-Secretory Adrenal Adenoma, Pheochromocytoma

Start: 2015-09-01End: 2024-09-01Updated: 2025-02-13

Readmission After Adrenalectomy

CompletedNCT06697652

Zagazig UniversityAdrenalectomy

Start: 2016-09-01End: 2024-09-01Updated: 2024-11-20

Genetic Predisposition to High Blood Pressure

Enrolling by invitationNCT07181213

Linkoeping UniversityGenetic Predisposition to Disease, Hypertension, Primary Aldosteronism

Start: 2026-01-01End: 2027-12-31Target: 76Updated: 2026-02-02

Cardiovascular Complications After Adrenalectomy for Pheochromocytoma and Non-secreting Tumors

Not yet recruitingNCT07200245

Central Hospital, Nancy, FranceAdrenal Incidentaloma, Cardiovascular Complication, Pheochromocytoma

Start: 2025-10-01End: 2027-12-31Target: 522Updated: 2025-10-01

Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension

Not yet recruitingNCT07470580

University Hospital, ToulouseAdrenalectomy, Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment

Start: 2026-04-01End: 2030-04-01Target: 134Updated: 2026-03-13

Related Papers

Long-Term Cardiac Effects of Adrenalectomy Versus Surveillance in Mild Cortisol Excess: 5-Year Results from the prospective ITACA Study.

2026-01-23

Randomized trial studying metabolic outcomes and quality of life after adrenalectomy versus conservative management for mild autonomous cortisol secretion

Endocrine Connections2025-07-011 citations

Molecular Imaging Versus Adrenal Vein Sampling for the Detection of Surgically Curable Primary Aldosteronism : A Prospective Within-Patient Trial.

2025-03-048 citations

Impact of Female Sex and Mild Cortisol Secretion on Coagulation Profile in Adrenal Incidentalomas

Journal of the Endocrine Society2024-11-264 citations

Predicting postoperative hypocortisolism in patients with non-aldosterone-producing adrenocortical adenoma: a retrospective single-centre study

Journal of Endocrinological Investigation2024-02-227 citations

A novel study, textbook outcome in adrenalectomy: retrospective observational study in an endocrine surgical unit.

2024-02-051 citations

FRI156 Novel Radiolabeled Ligand, Para-chloro-2-[18F]fluoroethyletomidate (CETO) Is Equivalent To [11C]metomidate-PET (MTO) For The Lateralisation Of Primary Aldosteronism (PA)

Journal of the Endocrine Society2023-10-01

[<sup>11</sup>C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial.

2023-01-1686 citations

First-in-human evaluation of [<sup>18</sup>F]CETO: a novel tracer for adrenocortical tumours.

2022-09-0822 citations

Treatment of Primary Aldosteronism and Reversal of Renin Suppression Improves Left Ventricular Systolic Function

Frontiers in Endocrinology2022-06-3028 citations

Adrenalectomy Improves Blood Pressure and Metabolic Control in Patients With Possible Autonomous Cortisol Secretion: Results of a RCT

Frontiers in Endocrinology2022-06-0247 citations

Coagulation parameters in asymptomatic patients with adrenal incidentaloma: is mild autonomous cortisol secretion correlated with thromboembolic risk?

Endocrine Abstracts2022-05-07

OR34-07 Prospective Multicentre Study Comparing 11C-metomidate PET CT with Adrenal Vein Sampling (AVS) in the Detection of Unilateral Aldosterone-Producing Adenomas (APAs)

Journal of the Endocrine Society2020-04-01