Abaloparatide

DRUG12 trials

Sponsors

Radius Health, Inc., Johns Hopkins University, University of Rochester, Hospital for Special Surgery, New York, University of Wisconsin, Madison

Conditions

Age Related OsteoporosisArthroplasties, Knee ReplacementChronic Myelomonocytic LeukemiaDegeneration Disc IntervertebralFemoral FracturesLumbar Degenerative DiseaseMyelodysplastic SyndromesOdontoid Fracture

Phase 1

A Phase I Pilot Study of Abaloparatide + Bevacizumab in Myelodysplastic Syndromes

CompletedNCT03746041

University of RochesterChronic Myelomonocytic Leukemia, Myelodysplastic Syndromes

Start: 2019-02-14End: 2022-06-06Updated: 2023-01-23

Phase 2

Effect of Abaloparatide on Lumbar Disc Degeneration

WithdrawnNCT03708926

Johns Hopkins UniversityDegeneration Disc Intervertebral

Start: 2021-03-31End: 2024-02-29Updated: 2021-04-12

Abaloparatide vs. Placebo in Post-Menopausal Women and Abaloparatide in Men Receiving Initial Spinal Fusion Surgery

Active, not recruitingNCT03841058

Hospital for Special Surgery, New YorkSpinal Fusion

Start: 2019-08-14End: 2027-02-01Target: 96Updated: 2026-04-28

PTH Analog Type II Odontoid Fracture

TerminatedNCT04760782

David LunardiniOdontoid Fracture

Start: 2022-05-18End: 2023-08-14Updated: 2024-09-19

The Effect of Osteoporotic Medications on Vertebral Bone Quality Score

Enrolling by invitationNCT07587775

State University of New York at BuffaloLumbar Degenerative Disease

Start: 2026-06-18End: 2028-12-31Target: 60Updated: 2026-07-23

Phase 3

Safety and Efficacy of Abaloparatide-SC in Men With Osteoporosis (ATOM)

CompletedNCT03512262

Radius Health, Inc.Age Related Osteoporosis, Osteoporosis, Osteoporosis, Age-Related +3

Start: 2018-05-03End: 2021-09-08Updated: 2023-04-07

Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption

CompletedNCT03710889

Radius Health, Inc.Osteoporosis, Osteoporosis, Age-Related, Osteoporosis Fracture +6

Start: 2018-09-20End: 2020-07-15Updated: 2021-10-15

Efficacy & Safety of Abaloparatide-Solid Microstructured Transdermal System in Postmenopausal Women With Osteoporosis

CompletedNCT04064411

Radius Health, Inc.Postmenopausal Osteoporosis

Start: 2019-08-05End: 2021-11-09Updated: 2023-02-15

Phase 4

Abaloparatide Before Total Knee Arthroplasty

CompletedNCT04167163

University of Wisconsin, MadisonArthroplasties, Knee Replacement, Osteoporosis

Start: 2020-01-10End: 2025-04-03Updated: 2026-06-05

Abaloparatide Added to Ongoing Denosumab vs Continued Denosumab Alone

Active, not recruitingNCT04467983

Hospital for Special Surgery, New YorkOsteoporosis, Postmenopausal

Start: 2021-02-01End: 2026-12-01Target: 70Updated: 2026-06-08

Supracondylar Distal Femur Fractures and Abaloparatide

WithdrawnNCT04626141

Daniel HorwitzFemoral Fractures

Start: 2024-06-30End: 2025-06-30Updated: 2024-05-01

Unknown Phase

Real-world Effectiveness and Cardiovascular Safety Study of Abaloparatide in Postmenopausal Women

CompletedNCT04974723

Radius Health, Inc.Osteoporosis, Postmenopausal

Start: 2021-07-01End: 2021-09-30Updated: 2024-04-19

Related Papers

Bone turnover markers predict changes in bone mineral density in men treated with abaloparatide: results from the abaloparatide for the treatment of men with osteoporosis (ATOM) study

Journal of Bone and Mineral Research2025-01-101 citations

6733 Bone Turnover Markers Predict Bone Mineral Density Increases With Abaloparatide In Men Similarly To Women: Results From ATOM

Journal of the Endocrine Society2024-10-01

Effects of Abaloparatide on Bone Mineral Density in Proximal Femoral Regions Corresponding to Arthroplasty Gruen Zones

Journal of Bone and Joint Surgery2024-05-016 citations

Response rates for lumbar spine, total hip, and femoral neck bone mineral density in men treated with abaloparatide: results from the ATOM study

JBMR Plus2024-01-274 citations

Efficacy and Safety of Transdermal Abaloparatide in Postmenopausal Women with Osteoporosis: A Randomized Study

Journal of Bone and Mineral Research2023-07-0720 citations

The Efficacy and Safety of Abaloparatide-SC in Men With Osteoporosis: A Randomized Clinical Trial.

2022-10-1826 citations

Comparative effectiveness and cardiovascular safety of abaloparatide and teriparatide in postmenopausal women new to anabolic therapy: A US administrative claims database study.

2022-05-0728 citations

Phase 1b Evaluation of Abaloparatide Solid Microstructured Transdermal System (Abaloparatide-sMTS) in Postmenopausal Women with Low Bone Mineral Density.

2021-02-2716 citations