7-hydroxystaurosporine

DRUG19 trials

Sponsors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Memorial Sloan Kettering Cancer Center, City of Hope Medical Center, National Cancer Institute (NCI), University of California, San Francisco

Conditions

Accelerated Phase Chronic Myelogenous LeukemiaAdenocarcinoma of the PancreasAdult Acute Megakaryoblastic Leukemia (M7)Adult Acute Minimally Differentiated Myeloid Leukemia (M0)Adult Acute Monoblastic Leukemia (M5a)Adult Acute Monocytic Leukemia (M5b)Adult Acute Myeloblastic Leukemia With Maturation (M2)Adult Acute Myeloblastic Leukemia Without Maturation (M1)

Phase 1

UCN-01 and Topotecan in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer

CompletedNCT00045175

University Health Network, TorontoFallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer

Start: 2002-06-30Updated: 2016-06-23

UCN-01 and Prednisone in Treating Patients With Solid Tumors or Lymphoma

CompletedNCT00045500

National Cancer Institute (NCI)Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific

Start: 2002-06-30Updated: 2015-04-30

UCN-01 and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer

CompletedNCT00039403

National Cancer Institute (NCI)Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer, Stage III Pancreatic Cancer +2

Start: 2002-04-30Updated: 2013-01-23

7-hydroxystaurosporine and Cisplatin in Treating Patients With Advanced Malignant Solid Tumors

TerminatedNCT00012194

National Cancer Institute (NCI)Unspecified Adult Solid Tumor, Protocol Specific

Start: 2001-03-31Updated: 2013-07-09

UCN-01 and Carboplatin in Treating Patients With Advanced Solid Tumors

CompletedNCT00036777

National Cancer Institute (NCI)Unspecified Adult Solid Tumor, Protocol Specific

Start: 2002-03-31Updated: 2013-07-01

UCN-01 and Irinotecan in Treating Patients With Advanced Solid Tumors

CompletedNCT00047242

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsUnspecified Adult Solid Tumor, Protocol Specific

Start: 2002-08-31Target: 30Updated: 2010-08-09

Combination Chemotherapy in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma

CompletedNCT00045513

University Health Network, TorontoLeukemia, Lymphoma

Start: 2002-06-30Updated: 2015-07-23

UCN-01 and Fludarabine in Treating Patients With Recurrent or Refractory Lymphoma or Leukemia

CompletedNCT00019838

National Cancer Institute (NCI)Leukemia, Lymphoma

Start: 1999-07-31Updated: 2015-04-29

7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

CompletedNCT00031681

National Cancer Institute (NCI)Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix, Estrogen Receptor-negative Breast Cancer +85

Start: 2001-12-31Updated: 2013-09-30

UCN-01, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or Unresectable Solid Tumors

CompletedNCT00042861

National Cancer Institute (NCI)Unspecified Adult Solid Tumor, Protocol Specific

Start: 2002-08-31Updated: 2015-04-30

Fluorouracil Plus UCN-01 in Treating Patients With Advanced or Refractory Solid Tumors

CompletedNCT00004059

Memorial Sloan Kettering Cancer CenterUnspecified Adult Solid Tumor, Protocol Specific

Start: 1999-07-31End: 2002-09-30Updated: 2013-06-21

UCN-01 and Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors

CompletedNCT00006464

City of Hope Medical CenterUnspecified Adult Solid Tumor, Protocol Specific

Start: 2001-03-31End: 2008-06-30Updated: 2010-01-15

UCN-01 in Treating Patients With Advanced Cancer

CompletedNCT00003289

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsLeukemia, Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific

Start: 1998-06-30Updated: 2010-08-09

7-Hydroxystaurosporine and Perifosine in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia or High Risk Myelodysplastic Syndromes

CompletedNCT00301938

National Cancer Institute (NCI)Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) +23

Start: 2005-12-31Updated: 2013-09-30

Phase 2

UCN-01 and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer

CompletedNCT00045747

Memorial Sloan Kettering Cancer CenterPancreatic Cancer

Start: 2002-07-31End: 2004-09-30Updated: 2013-06-24

UCN-01 in Treating Patients With Advanced or Metastatic Kidney Cancer

University of California, San FranciscoKidney Cancer

Start: 2002-12-31Updated: 2014-01-06

A Phase II Study of UCN-01 in Metastatic Melanoma

TerminatedNCT00072189

National Cancer Institute (NCI)Recurrent Melanoma, Stage IV Melanoma

Start: 2003-11-30End: 2010-03-31Updated: 2015-03-02

UCN-01 and Topotecan in Treating Patients With Recurrent, Persistent, or Progressive Advanced Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer

CompletedNCT00072267

University Health Network, TorontoFallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer

Start: 2004-01-31Updated: 2015-07-23

7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer

CompletedNCT00098956

National Cancer Institute (NCI)Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer

Start: 2005-01-31End: 2010-06-30Updated: 2018-07-23