5 mg tabletter

DRUG7 trials

Sponsors

Karolinska University Hospital, St. Olavs Hospital HF, Diakonhjemmet Sykehus AS, Karolinska Institutet, Toleranzia AB

Conditions

Acute mycocardial infarction (AMI)Erosive hand osteoarthritisLeft ventricular thrombosis.Myocardinal infarctionNon-functioning pituitary adenomaPatients with histologically (or via cytology) confirmed cancer that develop arthritis secondary to treatment with immune checkpoint inhibitors.Rheumatoid arthritisgeneralised myasthenia gravis

Phase 1

A double-blind, randomised, placebo-controlled, first-in-human (FIH) Phase I/IIa, multi-centre trial to assess safety, tolerability, and immune response of single and multiple ascending doses of TOL2 (Immune Tolerising Agent) in patients with generalised myasthenia gravis

Not yet recruitingCTIS2024-515627-10-00

Toleranzia ABgeneralised myasthenia gravis

Target: 42Updated: 2025-02-12

Phase 2

CITAR - Comparison of the efficacy and safety of early use of IL-6R blockade with tocilizumab in combination with short-term glucocorticoids versus glucocorticoids alone for the treatment of arthritis induced by cancer immunotherapy by check point inhibitors: a randomized, open, multicentre, proof of concept, superiority, controlled clinical trial

RecruitingCTIS2022-501130-33-00

Karolinska University HospitalPatients with histologically (or via cytology) confirmed cancer that develop arthritis secondary to treatment with immune checkpoint inhibitors.

Start: 2023-10-11Target: 57Updated: 2025-04-11

Phase 3

Danish trial of beta blocker treatment after myocardial infarction without reduced ejection fraction (DANBLOCK)

CompletedCTIS2024-515748-22-01

Frederiksberg HospitalMyocardinal infarction

Start: 2018-12-01End: 2025-04-01Target: 2760Updated: 2024-08-22

Phase 4

The Methotrexate in ERosive INflammatory Osteoarthritis (MERINO) trial: A randomized placebo-controlled trial to investigate clinical efficacy and safety of methotrexate in erosive inflammatory hand osteoarthritis

Active, not recruitingCTIS2023-510523-30-00

Diakonhjemmet Sykehus ASErosive hand osteoarthritis

Start: 2024-02-09Target: 163Updated: 2025-08-22

Utvärdering av två kortison behandlingsstrategier hos patienter med nydiagnostiserad, tidigare obehandlad reumatoid artrit: en randomiserad, öppen, non-inferiority, klinisk studie (OPRERA)

RecruitingCTIS2024-518775-54-00

Karolinska University HospitalRheumatoid arthritis

Start: 2021-10-05Target: 166Updated: 2025-10-01

An investigator-initiated, multicenter, open-label, parallel arm, active comparator, randomized study to compare the efficacy of apixaban versus warfarin with respect to thrombus resolution in patients with left ventricular thrombus after acute myocardial infarction.

RecruitingCTIS2024-514416-28-00

Karolinska InstitutetAcute mycocardial infarction (AMI), Left ventricular thrombosis.

Start: 2025-04-09Target: 212Updated: 2025-09-24

Dopamine agonist treatment of non-functioning pituitary adenomas (NFPAs) – a randomized controlled trial

RecruitingCTIS2023-510039-12-00

St. Olavs Hospital HFNon-functioning pituitary adenoma

Start: 2014-09-01Target: 60Updated: 2024-11-18

Related Papers

Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis.

2024-12-15