5 fluorouracil

DRUG18 trials

Sponsors

Institut de Recherche Clinique sur les Cancers et le Sang, Pfizer, Singapore National Eye Centre, Groupe Oncologie Radiotherapie Tete et Cou, Merrimack Pharmaceuticals

Conditions

Advanced Solid TumorEsophageal AdenocarcinomaGastric AdenocarcinomaGlaucomaHER-2 Gene AmplificationHead and Neck CancersMetastasisMetastatic Colorectal Cancer

Phase 1

Durvalumab in Combination With Docetaxel, Cisplatin and 5-FU for Locally Advanced Head and Neck Squamous Cell Carcinoma

TerminatedNCT02997332

Gustave Roussy, Cancer Campus, Grand ParisHead and Neck Cancers

Start: 2017-03-30End: 2022-12-01Updated: 2026-03-23

A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

RecruitingNCT06657144

Coherus Oncology, Inc.Advanced Solid Tumor, Metastatic Solid Tumor

Start: 2025-04-01End: 2028-01-01Target: 154Updated: 2026-03-31

Phase 2

A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic Adenocarcinoma

CompletedNCT01660711

Endeavor HealthPancreatic Adenocarcinoma

Start: 2012-07-31End: 2018-08-22Updated: 2021-11-08

Study of Nanoliposomal Irinotecan (Nal-IRI)-Containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma

CompletedNCT02551991

IpsenPancreatic Cancer

Start: 2015-10-19End: 2021-02-15Updated: 2022-10-10

Trial in Metastatic Colorectal Cancer With FOLFIRI Plus Aflibercept as First Line Treatment

Hellenic Oncology Research GroupMetastatic Colorectal Cancer

Start: 2016-01-31End: 2019-03-31Updated: 2019-02-22

Avelumab With Chemoradiation in Locally Advanced Rectal Cancer

CompletedNCT03299660

Peter MacCallum Cancer Centre, AustraliaRectal Cancer

Start: 2018-04-30End: 2023-02-28Updated: 2023-03-16

Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas

CompletedNCT03783936

Ashwin SomasundaramEsophageal Adenocarcinoma, Gastric Adenocarcinoma, HER-2 Gene Amplification +1

Start: 2019-01-24End: 2022-08-30Updated: 2023-12-19

Study of NALIRIFOX in Advanced Unresectable Small Bowel Tumors

RecruitingNCT06835387

Tiago Biachi de CastriaSmall Bowel Adenocarcinoma

Start: 2025-06-30End: 2028-08-01Target: 36Updated: 2026-02-17

Phase 3

Study Of FOLFIRI Chemotherapy With Or Without Sunitinib In Patients With Metastatic Colorectal Cancer

CompletedNCT00457691

PfizerMetastatic Colorectal Cancer

Start: 2007-06-30End: 2010-03-31Updated: 2015-03-30

Chemoradiotherapy HNSCC, Randomized Study, Docetaxel,Cisplatin, 5FU,Erbitux.

CompletedNCT01233843

Groupe Oncologie Radiotherapie Tete et CouSquamous Cell Head and Neck Carcinoma

Start: 2009-05-18End: 2018-11-06Updated: 2019-01-18

Study of MM-398 With or Without 5-FU/LV, Versus 5-FU/LV in Patients With Metastatic Pancreatic Cancer

CompletedNCT01494506

Merrimack PharmaceuticalsMetastatic Pancreatic Cancer

Start: 2011-11-30End: 2015-10-31Updated: 2016-06-17

Phase 4

Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants

CompletedNCT00138060

Institut de Recherche Clinique sur les Cancers et le SangMetastatic Colorectal Cancer

Start: 2005-06-30End: 2008-12-31Updated: 2010-07-20

5FU vs 5FU With Viscoelastic Formulation for the Prevention of Scarring Post-trabeculectomy

CompletedNCT00607685

Singapore National Eye CentreGlaucoma, Trabeculectomy, Wound Healing

Start: 2008-02-29End: 2010-01-31Target: 50Updated: 2010-05-12

Strategies for Management of Recurrent Pterygium

University of NottinghamRecurrent Pterygium

Start: 2017-01-31End: 2018-08-31Target: 25Updated: 2017-11-14

Unknown Phase

Evaluation of the Efficacy of Intralesional Injection of Combined Digoxin and Furosemide Versus 5 - Fluorouracil in Treatment of Plantar Warts

Sohag UniversityPlantar Wart

Start: 2022-07-01End: 2022-09-30Target: 60Updated: 2022-08-30

5-fluorouracil for Treatment of Stable Vitiligo

CompletedNCT06209138

Al-Azhar UniversityVitiligo

Start: 2024-01-23End: 2024-04-15Updated: 2024-04-17

Comparative Efficacy of Intralesional 5-Fluorouracil Versus Cryotherapy in the Treatment of Palmoplantar Warts: A Randomized Clinical Trial

Active, not recruitingPACTR202505517735790

Osama ElshaborySkin and Connective Tissue Diseases

Start: 2023-11-01Target: 60Updated: 2026-01-27

Microneedling Alone Versus Microneedling Coupled With Either Bleomycin or 5flourouracil in the Treatment of Plantar Warts

Not yet recruitingNCT07041749

Assiut UniversityWarts of Foot

Start: 2026-06-01End: 2027-07-01Target: 60Updated: 2025-06-27

Related Papers

Phase II study of NALIRIFOX (nanoliposomal irinotecan + oxaliplatin with fluorouracil and folinic acid) in advanced unresectable small bowel tumors.

Journal of Clinical Oncology2026-01-10

CHS-114: an afucosylated anti-CCR8 monoclonal antibody that selectively depletes intratumoral Treg cells and induces antitumor immune responses.

2025-12-22

Phase II study of avelumab and trastuzumab with FOLFOX chemotherapy in previously untreated HER2-amplified metastatic gastroesophageal adenocarcinoma.

2025-07-01

NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3 trial.

2023-09-11295 citations

Liposomal irinotecan + 5-fluorouracil/leucovorin + oxaliplatin (NALIRIFOX) versus nab-paclitaxel + gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (mPDAC): 12- and 18-month survival rates from the phase 3 NAPOLI 3 trial.

Journal of Clinical Oncology2023-06-013 citations

The Ave-Rec trial: Phase II trial of PD-L1/PD-1 blockade with avelumab plus chemoradiotherapy for locally advanced resectable T3B-4/N1-2 rectal cancer—Toxicity and interim efficacy data.

Journal of Clinical Oncology2023-06-012 citations

NAPOLI-3: A randomized, open-label phase 3 study of liposomal irinotecan + 5-fluorouracil/leucovorin + oxaliplatin (NALIRIFOX) versus nab-paclitaxel + gemcitabine in treatment-naïve patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).

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Population pharmacokinetics of liposomal irinotecan in patients with cancer and exposure–safety analyses in patients with metastatic pancreatic cancer

CPT Pharmacometrics & Systems Pharmacology2021-11-0911 citations

Abstract CT174: Phase II study of avelumab and trastuzumab with FOLFOX chemotherapy in previously untreated HER2-amplified metastatic gastroesophageal adenocarcinoma

Cancer Research2021-07-014 citations

Assessing real-world survival outcomes of patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with first-line FOLFIRINOX compared to patients from a phase 1/2 trial treated with NALIRIFOX.

Journal of Clinical Oncology2021-05-20

Phase I study of liposomal irinotecan in patients with metastatic breast cancer: findings from the expansion phase

Breast Cancer Research and Treatment2020-11-1744 citations

Early dose reduction/delay and the efficacy of liposomal irinotecan with fluorouracil and leucovorin in metastatic pancreatic ductal adenocarcinoma (mPDAC): A post hoc analysis of NAPOLI-1.

2020-10-109 citations

A phase II study of liposomal irinotecan with 5-fluorouracil, leucovorin and oxaliplatin in patients with resectable pancreatic cancer: the nITRO trial

Therapeutic Advances in Medical Oncology2020-01-0113 citations

Liposomal Irinotecan + 5-FU/LV in Metastatic Pancreatic Cancer

Pancreas2019-12-1930 citations

Abstract B14: CA 19-9 levels in patients with metastatic pancreatic adenocarcinoma receiving first-line therapy with liposomal irinotecan plus 5-fluorouracil/leucovorin and oxaliplatin (NAPOX)

Cancer Research2019-12-131 citations

Liposomal irinotecan in metastatic pancreatic adenocarcinoma in Asian patients: Subgroup analysis of the NAPOLI‐1 study

Cancer Science2019-12-0244 citations

Nomogram for Predicting Survival in Patients Treated with Liposomal Irinotecan Plus Fluorouracil and Leucovorin in Metastatic Pancreatic Cancer

Cancers2019-07-2829 citations

MINOAS: A Single-arm Translational Phase II Trial of FOLFIRI Plus Aflibercept as First-line Therapy in Unresectable, Metastatic Colorectal Cancer.

2019-06-019 citations

Phase II trial PD-L1/PD-1 blockade avelumab with chemoradiotherapy for locally advanced resectable T3B-4/N1-2 rectal cancer: The Ave-Rec trial.

Journal of Clinical Oncology2019-05-205 citations

Liposomal irinotecan and 5-fluorouracil/leucovorin in older patients with metastatic pancreatic cancer - A subgroup analysis of the pivotal NAPOLI-1 trial.

2019-03-0421 citations

37 more papers not shown