177Lu-Edotreotide
Sponsors
Grupo Espanol De Tumores Neuroendocrinos, Region Skane, ITM Solucin GmbH, Grupo Espanol de Tumores Neuroendocrinos
Conditions
Lung Neuroendocrine NeoplasmNeuroendocrine TumorsNeuroendocrine Tumors of GastroEnteric or Pancreatic Origin (GEP-NET)Neuroendocrine tumours of gastroenteric or pancreatic originPatients with well to moderately differentiated neuroendocrine tumors of the lung and thymus who require systemic therapy.Pediatric patients two years of age and above with somatostatin receptor positive (SSTR-positive) solid tumors or lymphomaSomatostatin receptor-positive (SSTR+)Thymus Neoplasms
Phase 1
Phase 3
Efficacy and Safety of Radiotherapy Compared to Everolimus in Somatostatin Receptor Positive Neuroendocrine Tumors of the Lung and Thymus.
RecruitingNCT05918302
Start: 2023-10-27End: 2028-07-01Target: 120Updated: 2026-03-06
Efficacy, safety and patient-reported outcomes of peptide receptor radionuclide therapy with 177Lu-edotreotide compared to everolimus in somatostatin receptor positive neuroendocrine tumors of the lung and thymus.
The LEVEL trial
RecruitingCTIS2022-502154-13-00
Start: 2023-10-27Target: 135Updated: 2025-07-17
A prospective, randomised, Controlled, Open-label, Multicentre phase III study to evaluate efficacy and safety of Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-Edotreotide compared to targeted molecular therapy with Everolimus in patients with inoperable, progressive, somatostatin receptor-positive (SSTR+), neuroendocrine tumours of gastroenteric or pancreatic origin (GEP-NET).
Active, not recruitingCTIS2023-510444-21-00
Start: 2017-11-24Target: 268Updated: 2025-11-24
A Prospective, Randomized, Controlled, Open-label, Multicenter Trial to Evaluate Efficacy, Safety and Patient-reported Outcomes of Peptide Receptor Radionuclide Therapy (PRRT) with Lutetium (177Lu) Edotreotide compared to Best Standard of Care in Patients with Well-differentiated Aggressive Grade 2 and Grade 3, Somatostatin Receptor‑positive (SSTR+), Neuroendocrine Tumors of GastroEnteric or Pancreatic Origin
Active, not recruitingCTIS2024-510812-64-00
Start: 2021-09-30Target: 153Updated: 2025-11-12
Systemic Targeted Adaptive RadioTherapy of NeuroEndocrine Tumors. An open-label, multi-center, randomized phase III trial comparing safety and efficacy of
personalized vs non-personalized radionuclide therapy with 177Lu-DOTATOC
RecruitingCTIS2023-508572-11-00
Start: 2022-06-21Target: 300Updated: 2025-10-22