Determining the optimal time interval for prophylactic intravenous ondansetron administration, and identifying factors associated with spinal hypotension after spinal anesthesia in non-obese pregnant woman undergoing cesarean section. Ondansetron, Maternal hypotension, Spinal hypotension, Cesarean Section
Conditions
Interventions
Ondansetron 4mg intravenous injection at least 10 minutes before spinal anesthesia
Prevention
Sponsors
None listed
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status II or III 2. Age 18 years or older 3. Full-term pregnancy (gestational age 37 weeks or more)
Exclusion criteria
Exclusion criteria: 1. Receipt of intravenous ondansetron less than 10 minutes prior to spinal anesthesia. 2. History of cerebrovascular disease 3. Obstetric complications (e.g., placental abruption, placenta previa) 4. Fetal abnormalities (congenital anomalies) 5. History of using monoamine oxidase inhibitors (MAOIs) or medications that prolong/delay cardiac conduction. 6. Administration of any other intravenous anesthetic agents prior to delivery, except for intravenous ondansetron, spinal anesthesia and spinal morphine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ondansetron to spinal anesthesia time interval Before spinal anesthesia Time in minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensory block level associated to spinal hypotension At 5 minutes after spinal aneshesia The level was defined as where the patient loses the ability to distinguish cold,Indication for cesarean section associated to spinal hypotension Before surgery Cephalopelvic Disproportion (CPD), Previous ceasarean section, Oligohydramnios, Premature rupture of membrane(PROM), Breech presentation | — |
Countries
Thailand
Contacts
Public ContactPariya Plicharoenpon
Chaoprayayommarat hospital
Outcome results
None listed