The efficacy of hyaluronic acid following open carpal tunnel release: A double blind randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260726010

Enrollment

Registered

2026-07-26

Start date

2026-02-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The efficacy of hyaluronic acid injection following open carpal tunnel release in patients with carpal tunnel syndrome that failed conservative treatment. Carpal Tunnel Syndrome

Interventions

Hylarulonic acid injection following open carpal tunnel release.,NSS injection following open carpal tunnel release.

Active Comparator Drug,Placebo Comparator Drug

Hyaluronic acid injection,Placebo

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age 20-80years old, 2. Diagnosis of carpal tunnel syndrome, 3. Fail conservative treatment for atleast 3months, 4. Inform consent

Exclusion criteria

Exclusion criteria: 1. History of carpal tunnel syndrome surgery, 2. Presence of thenar muscle atrophy, 3. Pregnancy, 4. Diabetes mellitus, 5. History of cervical spondylotic radiculopathy (CSR) or old cerebrovascular accidents (CVA), 6. Active breastfeeding, 7. History of allergy to hyaluronic acid

Design outcomes

Primary

Measure	Time frame
Functional outcome score 3months Boston carpal tunnel questionnaire score	—

Secondary

Measure	Time frame
Pain 1week, 1month, 3months Numerical rating scale (NRS)	—

Countries

Thailand

Contacts

Public ContactSupakorn Khajornchumsin

Thammasat University Hospital

supakorn.kha@gmail.com0944918199

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026