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Comparison of Neoplastic Cell Percentage of Malignant Mediastinal Lymph Node Tissue Obtained via Endobronchial Ultrasound-Guided Transbronchial Lymph Node Cryobiopsy (EBUS-TBLNC) versus Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)

Comparison of Neoplastic Cell Percentage of Malignant Mediastinal Lymph Node Tissue Obtained via Endobronchial Ultrasound-Guided Transbronchial Lymph Node Cryobiopsy (EBUS-TBLNC) versus Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA)

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20260726002
Enrollment
34
Registered
2026-07-26
Start date
2025-09-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic mediastinal lymph nodes from lung cancer EBUS-TBNA EBUS-TBLNC Lung cancer Neoplastic cell percentage

Interventions

Once the target location is identified, TBNA is performed using a 21-gauge needle (NA-201SX-4021, Olympus), which punctured through the bronchial wall into the target LN. A suction syringe is then att
Active Comparator Procedure/Surgery,Experimental Procedure/Surgery
EBUS-TBNA,EBUS-TBLNC

Sponsors

Faculty of Medicine, Chulalongkorn University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Individuals aged 18 years and older. 2. Suspected or diagnosed with non-small cell lung cancer 3. Prior CT scan or PET scan results indicate the presence of at least one mediastinal lymph node measuring no less than 1 cm in short axis, or FDG-PET uptake (SUVmax > 2.5). 4. The lymph node is accessible through EBUS. 5. Signed informed consent to participate in the research.

Exclusion criteria

Exclusion criteria: 1. Presence of abnormal, uncorrectable bleeding tendencies. 2. Severe arrhythmia. 3. History of coronary artery disease or unstable angina within 4 weeks prior to the procedure. 4. Severe upper airway obstruction which prevents the passage of the EBUS scope. 5. Ongoing active heart failure or respiratory failure

Design outcomes

Primary

MeasureTime frame
Neoplastic cell percentage after tissue was ready for pathological analysis percentage

Secondary

MeasureTime frame
Absolute tumor cell count after tissue was ready for pathological analysis cells,Procedural time after procedure was completed minutes

Countries

Thailand

Contacts

Public ContactKriengkrai Lummaetee

King Chulalongkorn Memorial Hospital

krkrlum@gmail.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026