Major breast surgery, Postoperative analgesia, Chronic post surgical pain Nefopam, Parecoxib, Postoperative analgesia, Major breast surgery, Chronic post surgical pain
Conditions
Interventions
Nefopam 80 mg intravenous infusion in 500 mL of normal saline in 24 hours,Parecoxib 40 mg intravenous bolus every 12 hours
Active Comparator Drug,Active Comparator Drug
Nefopam,Parecoxib
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective unilateral major breast surgery including mastectomy, mastectomy with sentinel lymph node biopsy and modified radical mastectomy, 2. Age 20 to 65 years old, 3. ASA physical class 1 to 3
Exclusion criteria
Exclusion criteria: 1. Known allergy to study drugs including nefopam, paracetamol, parecoxib, fentanyl, morphine, 2. Contraindication to nefopam administration, 3. Contraindication to parecoxib administration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cumulative morphine consumption At 24 hours postoperative Postoperative cumulative morphine consumption | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic post surgical pain At 3 months postoperative Chronic post surgical pain,Incidence of opioid related side effects within 48 hours postoperative Incidence of opioid related side effects,numerical pain score at rest and movement 24 hours postoperative numerical pain score at rest and movement | — |
Countries
Thailand
Contacts
Public ContactChayaporn Kraiwitchaicharoen
Department of Anesthesiology, Faculty of Medicine, Khon Kaen University
Outcome results
None listed