Vitamin D Supplementation for Carpal Tunnel Syndrome

Vitamin D Supplementation as an Adjunct to Conservative Treatment for Carpal Tunnel Syndrome: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260721002

Enrollment

Registered

2026-07-21

Start date

2022-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal Tunnel Syndrome Carpal Tunnel Syndrome Vitamin D Ergocalciferols Randomized Controlled Trial Placebos Pain Measurement Grip Strength

Interventions

Oral vitamin D2 (ergocalciferol) 40,000 IU per week, administered as 20,000 IU every 3-4 days, for 12 weeks, in addition to standard conservative treatment for carpal tunnel syndrome (analgesics, NSAI

Experimental Drug,Placebo Comparator Other

Vitamin D2 (Ergocalciferol) Supplementation,Placebo

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. adults with clinically diagnosed CTS based on characteristic symptoms and physical examination findings. Electrodiagnostic studies were performed when clinically indicated to confirm the diagnosis

Exclusion criteria

Exclusion criteria: 1. medical conditions requiring vitamin D supplementation, such as osteoporosis 2. diabetes mellitus 3. rheumatoid arthritis 4. pregnancy or breastfeeding 5. current use of anticonvulsants, rifampicin, or thrombolytic agents 6. known hypersensitivity to vitamin D or corn starch 7. receipt of vitamin D supplementation within 12 weeks prior to enrollment.

Design outcomes

Primary

Measure	Time frame
Pain intensity Baseline, 4 weeks, and 12 weeks after randomization Visual Analog Scale (VAS)	—

Secondary

Measure	Time frame
Grip strength Baseline, 4 weeks, and 12 weeks after randomization JAMAR hydraulic hand dynamometer,Symptom severity Baseline, 4 weeks, and 12 weeks after randomization Thai version of the Boston Carpal Tunnel Questionnaire - Symptom Severity Scale (SSS),Functional status Baseline, 4 weeks, and 12 weeks after randomization Thai version of the Boston Carpal Tunnel Questionnaire - Functional Status Scale (FSS),Vitamin D toxicity At each follow-up visit during the 12-week treatment period Clinical monitoring of signs and symptoms of vitamin D toxicity	—

Measure

Time frame

Grip strength Baseline, 4 weeks, and 12 weeks after randomization JAMAR hydraulic hand dynamometer,Symptom severity Baseline, 4 weeks, and 12 weeks after randomization Thai version of the Boston Carpal Tunnel Questionnaire - Symptom Severity Scale (SSS),Functional status Baseline, 4 weeks, and 12 weeks after randomization Thai version of the Boston Carpal Tunnel Questionnaire - Functional Status Scale (FSS),Vitamin D toxicity At each follow-up visit during the 12-week treatment period Clinical monitoring of signs and symptoms of vitamin D toxicity

—

Countries

Thailand

Contacts

Public ContactSawitt Sirasittikarn

Department of Orthopaedic Surgery, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University

sawitt.097@gmail.com0979912304

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026