postmenopausal women with hypoactive sexual desire disorder Postmenopause Sexual Desire Disorders
Conditions
Interventions
1% testosterone gel 1/10 sachets apply OD,Placebo gel (medical grade without active ingredient) 1/10 sachets apply OD
Active Comparator Drug,Placebo Comparator Drug
Androgel,Placebo
Sponsors
Ratchadapisek Research Funds
Eligibility
Sex/Gender
Female
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Postmenopausal women aged 35 - 70 year olds 2. Diagnosed with hypoactive sexual desire using the Decreased Sexual Desire Screener (DSDS) 3. In a stable relationship with a male partner for at least 1 year, and the partner is able to engage in sexual activity. 4. Willing to participate in the study and provide written informed consent. 5. Able to read and communicate in Thai. 6. Baseline total testosterone level < 80 ng/dL before enrollment.
Exclusion criteria
Exclusion criteria: Have severe underlying medical conditions, including: 1. History of atherosclerotic cardiovascular disease, including previous myocardial infarction or stroke. 2. Metabolic syndrome 3. Severe hypertension (systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg). 4. LDL cholesterol >190 mg/dL. 5. Any contraindication to testosterone therapy. 6. Liver disease with AST or ALT >2 times the upper limit of normal. 7. History of depression or other psychiatric disorders within the past 12 months,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sexual desire 3 months FSFI-19 desire domain | — |
Secondary
| Measure | Time frame |
|---|---|
| Sexual function 3 months FSFI-19 total score,Depression 3 months PHQ-9 | — |
Countries
Thailand
Contacts
Public ContactNuttida Mahakit
king chulalongkorn memorial hospital
Outcome results
None listed