Orthodontic patients with the informed consent who has been indicated for bilateral maxillary first premolar extraction and canine retraction. Superoxide dismutase (SOD), Fixed orthodontic treatment, Gingival crevicular fluid (GCF)
Conditions
Interventions
Maxillary canines with distalization force using nickel-titanium closed coil spring on labial side with 150-g retraction force,Maxillary canines without distalization force
Basic Science,Basic Science
OTM group,Control group
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
12 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Orthodontic patients who has been indicated for bilateral maxillary first premolar extraction and canine retraction. 2. No systemic diseases, allergies, consumption of medication or alcohol, previous or current smoking, pregnancy, any signs and symptoms of periodontal diseases (periodontal depth and/or clinical attachment loss more than 3 mm, or radiographic evidence of alveolar bone loss), or previous orthodontic treatment will be excluded from this study. All patients will be received proper oral hygiene instruction and the periodontal evaluation will be performed at each time point using gingival index (GI) and plaque index (PI) described by Silness and Loe. If either GI or PI score is more than 0.9 that individual will be exclude from this study.
Exclusion criteria
Exclusion criteria: 1. Patients with any systemic diseases or allergies 2. Patients with consumption of medication or alcohol 3. Previous or current smokers 4. Pregnant patients 5. Any signs and symptoms of periodontal diseases (periodontal depth and/or clinical attachment loss more than 3 mm, or radiographic evidence of alveolar bone loss) 6. Previous orthodontic treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Superoxide dismutase (SOD) activity At before starting canine retraction, 1 day after canine retraction, 1 week after canine retraction, and 1 month after canine retraction. Using commercial SOD activity assay kits following the manufacturer's instructions.,SOD3 protein level At before starting canine retraction, 1 day after canine retraction, 1 week after canine retraction, and 1 month after canine retraction. SOD3 ELISA kit | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of tooth movement Before starting canine retraction and 1 month after retraction. Measuring distance between distal surface of maxillary lateral incisor and mesial surface of maxillary canine from intraoral scans. | — |
Countries
Thailand
Contacts
Public ContactSirichom Satrawaha
Orthodontic Department, Faculty of Dentistry, Chulalongkorn University
Outcome results
None listed