Vitamin D deficiency patients in total knee arthroplasty Osteoarthritis knee Total knee arthroplasty Vitamin D deficiency
Conditions
Interventions
Patients took weekly calciferol capsules for 24 weeks.
The treatment group received 60,000 IU per week from true calciferol 3 capsule
,And the control group received 20,000 IU per week from true calc
Experimental Drug,Placebo Comparator Drug
Postoperative TKA give vitamin D 60,000 IU per week,Postoperative TKA give vitamin D 20,000 IU per week
Sponsors
Kittitouch Ohpassatchakul
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria : 1.elderly patients with OA knee age 60-80 years 2.underwent unilateral TKA 3.serum 25(OH)D level < 30 ng/mL
Exclusion criteria
Exclusion criteria: Exclusion criteria : 1.received additional vitamin D in calcium or multivitamin supplementation in last 3 month 2.underlying Thyroid/Parathyroid dysfunction, Osteomalacia, Chronic kidney disease stage3-5 (eGFR < 60 ml/min), Rheumatoid arthritis, Other inflammatory arthritis, Kidney stone 3.patients with medical problems that affect vitamin D absorption and metabolism such as short bowel syndrome, granulomatous disorders, patients who received anticonvulsants, rifampicin, cholestyramine, antiretrovirals patients with hypercalcemia or hyperphosphatemia 4.History of vitamin D supplement allergy 5.History of malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional outcomes postoperative TKA 6th ,12th,24th weeks The Western Ontario and McMaster Universities Arthritis Index (WOMAC) | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score postoperative TKA 6th ,12th ,24th weeks Visual analog scale (VAS) ,serum 25(OH)D level baseline, 6th, 12th ,24th weeks serum 25(OH)D level | — |
Countries
Thailand
Contacts
Public ContactKittitouch Ohpassatchakul
Ramathibodi
Outcome results
None listed