postmenopausal women with osteoporosis Postmenopausal osteoporosis, Acute phase response, Dexamethasone, Acetaminophen
Conditions
Interventions
Dexamethasone group take a Dexamethasone 4 mg, 1.5 hr before get Zoledronate injection
then take a Dexamethasone 4 mg in day 2,3 once a day in the morning ,Acetaminophen group take Acetaminophen 500
in the morning, noon, evening, bedtime (16:00, 22:00, 6:00, 12:00)
Active Comparator Drug,Active Comparator Drug
Dexamethasone,Acetaminophen
Sponsors
Mahawajiralongkorn foundation
Eligibility
Sex/Gender
Female
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. postmenopausal women 45- 90 year old 2. Follow up osteoporosis treatment with Zoledronate at Phramongkutklao Hospital
Exclusion criteria
Exclusion criteria: 1. have underlying diseases as Diabetes mellitus, Glaucoma, myocardial infarction, poor controlled hypertension (BP > 160/90), Chronic kidney disease stage 4 (GFR < 30), Malignant tumor 2. Allergy to Glucocorticoids/ Acetaminophen/ NSAIDs 3. Active in clinical of infection or suspected in Acute or Chronic infection and immunocompromised patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of oral temperature from baseline within 72 hour after zoledronate injection degree celsius | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical severity of acute phase response within 72 hour after zoledronate injection VAS score ,Rescue medication usage within 72 hour after zoledronate injection amount of used rescue medication ,incidence of acute phase response from Zoledronate within 72 hour after zoledronate injection percentage | — |
Countries
Thailand
Contacts
Public ContactSuthita Phoesena
Orthopedics department of Phramongkutklao hospital and college of medicine
Outcome results
None listed