Psychiatric disorder requiring electroconvulsive therapy electroconvulsive therapy seizure quality hyperventilation end-tidal CO2
Conditions
Interventions
Hyperventilation was administered via facemask at a rate of at least 20 insufflations per minute with EtCO2 monitoring, and the procedure continued until the EtCO2 target of 30 mmHg or less was reache
Experimental Procedure/Surgery,Active Comparator Procedure/Surgery
Hyperventilation with EtCO2 monitoring (EtCO2 protocol),Conventional hyperventilation (Conventional protocol)
Sponsors
Faculty of Medicine, Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Diagnosis of major depressive disorder (MDD), bipolar disorder, schizophrenia, schizoaffective disorder, or treatment resistant dementia with BPSD 2) Indicated for receiving ECT at Siriraj Hospital 3) No change in ECT parameters and medications for at least 2 sessions of ECT prior to the study
Exclusion criteria
Exclusion criteria: 1) Severe or unstable cardiovascular disease e.g., recent myocardial infarction, unstable angina, poorly compensated congestive heart failure, severe valvular cardiac disease, or have an episode of these conditions within 1 month 2) Aneurysm or vascular malformation 3) Have signs of increase intracranial pressure or have brain tumor or space-occupying cerebral lesions 4) Recent cerebral infarction/hemorrhage within 1 month 5) Pulmonary condition e.g., COPD/asthma with acute exacerbation, pneumonia within 1 month 6) American Society of Anesthesiologists (ASA) class 4 or 5 7) Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure quality during intervention seizure duration and Glenside EEG Rating Scale for ECT (GERSE) | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects and adverse events Immediately after intervention Clinical assessment,Hemodynamic parameters before anesthetic induction, immediately after the ECT stimulus dose was delivered, and before participants were transferred to the recovery room Clinical assessment | — |
Countries
Thailand
Contacts
Public ContactKantanut Yutritak
Mahidol University
Outcome results
None listed