Effects of V-FOS L95 fructooligosaccharide consumption on biomarkers of gut microbiota

Effects of V-FOS L95 fructooligosaccharide consumption on biomarkers of gut microbiota modulation, lipid profile, and immune function in healthy adults: a randomized, double-blind, and placebo-controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260711015

Enrollment

Registered

2026-07-11

Start date

2026-08-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants fructooligosaccharide, gut microbiome, immune function, lipid profil, prebiotic

Interventions

5 g of medium invert sugar twice daily,5 g of FOS content twice daily

Placebo Comparator Dietary Supplement,Active Comparator Dietary Supplement

Placebo,V-FOS L95

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Healthy male and female participants aged 18-50 years who provide informed consent to participate in the research study 2. Body Mass Index (BMI) within the range of 18.5-25 kg/m2 3. Blood glucose level less than 100 mg/dL 4. Blood triglyceride level less than 150 mg/dL 5. Blood urea nitrogen (BUN) and creatinine within the range of 8-24 mg/dL and 0.84-1.21 mg/dL, respectively 6. Aspartate transaminase (AST) and alanine transaminase (ALT) within the range of 8-48 U/L and 7-55 U/L, respectively. 7. Blood pressure not exceeding 120/80 mmHg. 8. Willing to participate in all study activities and provide all necessary data for the study

Exclusion criteria

Exclusion criteria: 1. History of regular smoking or alcohol consumption 2. Use of antibiotics within 3 months prior and during the study 3. Consumption of foods or supplements containing probiotics, prebiotics, or synbiotics within 1 month prior and during the study 4. History of dietary fiber intolerance (or history of inability to consume dietary fiber) 5. Pregnancy (confirmed by a urine pregnancy test)

Design outcomes

Primary

Measure	Time frame
Gut microbiome After 8 weeks of intervention, and 2 week of washout period 16s rRNA gene sequencing ,Stool characteristic data After 8 weeks of intervention, and 2 week of washout period Questionnaire	—

Secondary

Measure	Time frame
Caloric intake After 8 weeks of intervention, and 2 week of washout period 3-day food record,Fecal short-chain fatty acids After 8 weeks of intervention, and 2 week of washout period Gas Chromatography-Flame Ionization Detector (GC-FID),Blood lipid profiles, fasting blood glucose, inflammatory cytokines After 8 weeks of intervention Assay kits, chemical reactions	—

Countries

Thailand

Contacts

Public ContactSuvimol Charoensiddh

Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University

suvimol.ch@ku.th025625020

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026