To evaluate the influence of routine Quran recitation on psychological states (depression, anxiety, and stress), SERCA2a gene expression, and echocardiographic parameters (LVOT VTI and Ejection Fraction [EF]) among heart failure with reduced ejection fraction (HFrEF) patients. Quran recitation
Conditions
Interventions
Active intervention group instructed to routinely recite 1 juz of the Holy Quran per day.,Active intervention group instructed to routinely recite half juz of the Holy Quran per day.,Control group mai
Daily Holy Quran Recitation (1 Juz per Day) plus Standard Heart Failure Therapy,Daily Holy Quran Recitation half Juz per day plus Standard Therapy,Standard Therapy Alone
Sponsors
Faculty of Medicine, Universitas Syiah Kuala
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. male or female 2. patients aged 30 to 65 years 3. diagnosed with stable HFrEF for more than 3 months 4. actively receiving standard-of-care heart failure pharmacological therapies (including sacubitril/valsartan, angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs), alongside beta-blockers, mineralocorticoid receptor antagonists (MRAs), statins, furosemide, and antiplatelets) 5. presenting with a baseline left ventricular ejection fraction (LVEF) between 15% and 40% 6. and having no history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) within the past 6 months.
Exclusion criteria
Exclusion criteria: 1. a history of stroke with residual neurological sequelae 2. active acute or chronic inflammatory diseases 3. severe valvular stenosis 4. Participants were dropped out from the study if they experienced acute decompensated heart failure (ADHF) or underwent emergency coronary interventions during the trial period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sarcoplasmic reticulum calcium ATPase 2a gene expressio, Left ventricular ejection fraction 15 days, 30 days qRT-PCR, echocardiography | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression score, Anxiety score, Stress score, Left ventricular outflow tract velocity time integral, 15 days, 30 days Depression score, Anxiety score, Stress score, Echocardiography | — |
Countries
Indonesia
Contacts
Public ContactNurkhalis Nurkhalis
Street. Tgk Syech Abdul Rauf, Kopelma Darussalam, Syiah Kuala District, Banda Aceh City, Aceh
Outcome results
None listed