The study includes patients diagnosed with either Major Depressive Disorder (MDD) or Persistent Depressive Disorder (PDD) based on DSM-5-TR criteria, including those with and without a history of suicide attempts. Major Depressive Disorder (MDD) Persistent Depressive Disorder (PDD) Suicide Gene polymorphism Serotonergic system
Conditions
Interventions
1. Male/female volunteers aged between 18 and 65 years.
2. Volunteers who do not have severe stress based on the Stress Assessment Form (SPST-20).
3. Volunteers who consent to participate in the res
Healthy volunteers,Depressed patients without suicidal history,Depressed patients with suicidal history
Sponsors
Naresuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Experimental Group (Depressed Patients) 1. Male or female patients with depression aged 18 to 65 years 2. Patients diagnosed with Major Depressive Disorder (MDD) or Persistent Depressive Disorder (PDD) by a psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) 3. Patients who voluntarily agree to participate in the study and provide written informed consent 4. Patients who can read, listen, and write in the Thai language Control Group (Healthy Volunteers) 1. Male or female patients with depression aged 18 to 65 years 2. Volunteers without severe stress, as determined by the Suanprung Stress Test-20 (SPST-20) 3. Volunteers who voluntarily agree to participate in the study 4. Volunteers who can read, listen, and write in the Thai language
Exclusion criteria
Exclusion criteria: Experimental Group (Depressed Patients) 1. Patients with severe depression who are unable to provide informed consent 2. Patients with a history of substance abuse (e.g., methamphetamine, ecstasy, cannabis, heroin, opium, morphine, cocaine, kratom, or inhalants) within the past 6 months 3. Patients with a history of chronic alcoholism (Alcohol Use Disorder) 4. Patients who are currently pregnant 5. Patients who are unwilling to provide information Control Group (Healthy Volunteers) 1. Volunteers with stress or anxiety, as determined by the Suanprung Stress Test-20 (SPST-20), reaching a severe level 2. Volunteers with a history of substance abuse (e.g., methamphetamine, ecstasy, cannabis, heroin, opium, morphine, cocaine, kratom, or inhalants) within the past 6 months 3. Volunteers with a history of chronic alcoholism (Alcohol Use Disorder) 4. Volunteers who are currently pregnant 5. Volunteers who are unwilling to provide information
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between genetic polymorphisms in serotonin system and suicide attempts in major depressive disorder patients at enrollment to each group Real-Time PCR System | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between genetic polymorphisms in serotonin system and major depressive disorder patients at enrollment to each group Real-Time PCR System | — |
Countries
Thailand
Contacts
Public ContactSutisa Thanoi
Faculty of Medical Science, Naresuan University
Outcome results
None listed