Patients with periorbital wrinkles Periorbital rejuvenation Picosecond laser Microfocused ultrasound Split-face trial Dihydromyricetin Crow'
Conditions
Interventions
Participants receive a single treatment with fractional 1,064-nm picosecond Nd:YAG laser (Pico-K) on one side of the periorbital area using a micro-lens array handpiece (spot size 12 mm, fluence 0.2 J
Experimental Device,Experimental Device
Fractional Picosecond Nd:YAG Laser,Microfocused Ultrasound (Ultherapy)
Sponsors
Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female aged 18 years or older. 2. Good general health. 3. Bilateral periorbital wrinkles of at least grade 1 according to the Crow's Feet at Rest Merz Assessment Scale.
Exclusion criteria
Exclusion criteria: 1. Corneal disease or infection preventing the use of contact eye shields. 2. Active infection, inflammation, or immune-mediated skin disease involving the periorbital area. 3. Botulinum toxin treatment to the periorbital area within the previous 6 months. 4. Filler injection to the malar, infraorbital, or temporal area within the previous 12 months. 5. Microfocused ultrasound treatment to the face within the previous 12 months. 6. Collagen-stimulating injectable treatment to the malar, infraorbital, or temporal area within the previous 24 months, including poly-D-L-lactic acid, poly-L-lactic acid, calcium hydroxylapatite, or polycaprolactone. 7. Thread lifting treatment within the previous 24 months. 8. Laser treatment, dermabrasion, chemical peeling, radiofrequency treatment, or any other aesthetic procedure involving the periorbital treatment area within the previous 6 months. 9. Use of retinoid products within 3 months before enrollment. 10. Known allergy to Eucerin hyaluron-filler Epicilline serum. 11. Known allergy to Eucerin sun spotless brightening serum. 12. Pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periorbital wrinkle improvement Baseline, Weeks 4, 8, 16 and 20 Measured using Antera 3D imaging system (Texture, pigmentation, fine wrinkle, wrinkle), Crow's Feet at Rest Merz Assessment Scale, and Global Aesthetic Improvement Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score Immediately after treatment Visual Analog Scale (VAS),Patient satisfaction Weeks 4, 8, 16 and 20 Visual Analog Scale (VAS) | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed