Gestational diabetes mellitus GDM, ELA, parturients, newborns
Conditions
Interventions
Laboring women diagnosed with diet-controlled gestational diabetes mellitus (White class A1) according to the Vietnam Ministry of Health guideline (Decision 1470/QD-BYT, 2024), based on a positive 75
Prevention,Prevention
GDM Group (Gestational Diabetes Mellitus Group),Group 2: Non-GDM Group (Control Group)
Sponsors
None listed
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Pregnant women aged 18 to 40 years 2.Singleton pregnancy, cephalic presentation 3.Gestational age 37 to 42 weeks, planned for vaginal delivery 4.Cervical dilation 3 to 4 centimeters at the time of epidural catheter placement 5.American Society of Anesthesiologists (ASA) physical status I to II, with no major underlying medical illness 6.Willing and consenting to receive epidural labor analgesia 7.For the gestational diabetes group: diagnosed with gestational diabetes mellitus according to the Vietnam Ministry of Health guideline (Decision 1470/QD-BYT, 2024), based on the 75 gram, 2 hour oral glucose tolerance test, managed by diet and exercise only, without insulin treatment 8.For the comparison group: negative result on the above oral glucose tolerance test performed during the same period of pregnancy
Exclusion criteria
Exclusion criteria: 1.Pre-existing type 1 or type 2 diabetes diagnosed before pregnancy 2.Gestational diabetes mellitus requiring insulin treatment 3.Endocrine disorders affecting cortisol or glucose metabolism, such as Cushing syndrome or adrenal insufficiency 4.Severe preeclampsia, eclampsia, complete placenta previa, prior uterine scar, or threatened uterine rupture 5.Fetal growth restriction, severe polyhydramnios, or severe oligohydramnios 6.Current use of systemic corticosteroids, or last dose taken less than 72 hours before the onset of labor 7.Contraindication to epidural analgesia, or refusal of the procedure by the patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maternal intrapartum blood glucose Hourly from epidural placement (T0) until end of third stage Capillary glucose (mmol/L),Neonatal blood glucose Cord clamping; 1 hour after birth Cord arterial glucose and heel-prick glucose (mmol/L) | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal serum cortisol T0 and T0+2h Serum cortisol (nmol/L), venous blood sample,Umbilical arterial blood gas Immediately after cord clamping Arterial cord blood: pH, PaCO2, PaO2, HCO3, base excess, lactate | — |
Countries
Vietnam
Contacts
Public ContactTu Nguyen
Hanoi Medical University
Outcome results
None listed