Skull pin insertion is a highly noxious stimulus that can provoke significant stress and hemodynamic changes. If anesthesiologist cannot control or attenuate this response during craniotomy operation, it could be make an adverse effects such as intracranial hemorrhage or myocardial infarction. Craniotomy, skull-pin head-holder insertion, Hemodynamic response, metabolic response, dexmedetomidine, fentanyl, cortisol, plasma glucose level, cytokine, neutrophil to lymphocyte ratio (NLR)
Conditions
Interventions
The dexmedetomidine group received a loading dose of dexmedetomidine 0.5 mcg/kg over 10 minutes before induction of general anesthesia, followed by an infusion of 0.5 mcg/kg/h until 30 minutes after s
Experimental Drug,Active Comparator Drug
Dexmeditomidine,fentanyl
Sponsors
The Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.The patients who were scheduled for elective craniotomy, 2.ASA physical status 1-2
Exclusion criteria
Exclusion criteria: 1.Allergy to dexmeditomidine, fentanyl or any medications for general anesthesia, 2.Bradycardia heart rate below 60bpm or current beta blocker medication, 3.Current clonidine medication, 4.Glasgow coma scale below 15, 5.Alcohol or substance abuse, 6.Pregnancy or breast feeding, 7.Psychological disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol level 30 minutes after skull pin insertion Change in cortisol level | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamics responses 30 minutes after skull pin insertion blood pressure, heart rate,,Glucose 30 minutes after skull pin insertion Change in blood glucose level,N:L ratio 30 minutes after skull pin insertion change in neutrophil and lymphocyte ratio | — |
Countries
Thailand
Contacts
Public ContactKornkamon Yuwapattanawong
Chulalongkorn memorial hospital
Outcome results
None listed