Neurosurgical conditions which are required to undergo elective intracranial Dexmedetomidine propofol-based anesthesia
Conditions
Interventions
an infusion rate of 4 mL/h for 4 hours, total volume (16 mL) of 0.9% NaCl solution for the control group,an infusion rate of 4 mL/h for 4 hours, total volume (16 mL) of Dexmedetomidine 0.2 microgram/
Group C,Group 0.2,Group 0.4
Sponsors
Faculty of Medicine CMU
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who are scheduled for elective craniotomy from March 1, 2023 to February 28, 2026 1. Age 18 - 65 years old 2. American Society of Anesthesiologists (ASA) 1-3 3. Glasgow Coma Scale (GCS) 14, 15
Exclusion criteria
Exclusion criteria: 1. Second- or third-degree atrioventricular (AV) block 2. Baseline heart rate (HR) less than 60 per min 3. Ventricular dysfunction 4. Hepatic impairment 5. Chronic kidney disease (CKD) stage 4 or 5 6. Pregnancy 7. Morbid obesity 8. On medication with alpha -methyldopa, clonidine 9. Require intraoperative neuromonitoring (IONM), which no need for neuromuscular blockade 10. Currently receive > 2 kinds of antiepileptic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| propofol consumption Intraoperative dose during neurosurgery propofol dose ,Fentanyl consumption Intraoperative dose during neurosurgery fentanyl dose | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure before, during, after study drug infusion Blood pressure,adverse hemodynamic events during, after study drug infusion blood pressure, heart rate | — |
Countries
Thailand
Contacts
Public ContactAnanchanok Saringcarinlul
Faculty of Medicine, Chiangmai University
Outcome results
None listed