Post-intubation hyperdynamic alteration after propofol induction and post-induction hypotension. Propofol, post-intubation hypertension, post-induction hypotension.
Conditions
Interventions
Aneshtesia induction with propofol 2 mg/kg IV,propofol 1.5 mg/kg IV for induction with propofol 0.5 mg/kg 30 seconds before tracheal intubation
Active Comparator Other,Active Comparator Other
The control group,The split-dose group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years. 2. American Society of Anesthesiologists (ASA) physical status classification I or II. 3. Undergoing elective non-cardiac surgery under general anesthesia with endotracheal tube.
Exclusion criteria
Exclusion criteria: 1. History of hypersensitivity to propofol, soy bean and egg lecithin. 2. Hypertensive participants who consumed angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB). 3. Blood pressure before the induction of anesthesia more than 160/100 mmHg or less than 90/60mmHg, heart rate less than 60 bpm or more than 120 bpm 4. Anticipated difficult airway. 5. At risk of full stomach. 6. Body mass index more than or equal 30 kg/m2. 7. History of Arrhythmia e.g. premature ventricular contraction, atrial fibrillation, atrial flutter, mobitz type I, mobitz type II, third degree AV block, ventricular tachycardia, wolff-parkinson-white syndrome, supraventricular tachycardia. 8. Participants who required propofol titration during induction, or those unable to receive the dose as specified in the protocol. 9. Unsuccessful intubation at the first time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| post-intubation hyperdynamic response immediate post-intubation mean arterial pressure in units of millimeters of mercury (mmHg) | — |
Secondary
| Measure | Time frame |
|---|---|
| other hemodynamic parameter from induction to 5 minutes after intubation systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate in units of millimeters of mercury (mmHg),the change in mean arterial pressure from baseline to immediate post-intubation, and from pre-intubation to immediate post-intubation mean arterial pressure in units of millimeters of mercury (mmHg),incidence of post induction hypotension from induction to 5 minutes after intubation mean arterial pressure in units of millimeters of mercury (mmHg) | — |
Countries
Thailand
Contacts
Public ContactPariya Plicharoenpon
Chaoprayaymmarat hospital
Outcome results
None listed