Colorectal diseases Colonoscopy sedation Procedural sedation Colonoscopy Sedation Propofol Ketamine Fentanyl Ketofol Fenofol
Conditions
Interventions
Participants will receive intravenous ketamine 0.5 mg/kg combined with propofol 1 mg/kg for sedation during colonoscopy. Additional doses of the study medication may be administered to maintain the ta
Experimental Drug,Active Comparator Drug
Propofol Ketamine (Ketofol),Propofol Fentanyl (Fenofol)
Sponsors
Dr.Nutthineenart Tongdee
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective colonoscopy at Sikhoraphum Hospital. 2. American Society of Anesthesiologists Physical Status Classification I to III. 3. Able to understand the study procedures and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Known allergy or hypersensitivity to propofol, ketamine, fentanyl, egg, soy, or soybean products. 2. Pregnancy or breastfeeding. 3. History of psychiatric disorders or neurological conditions that may interfere with sedation assessment. 4. Severe cardiovascular or respiratory disease. 5. Severe hepatic or renal impairment. 6. Uncontrolled hypertension. 7. Use of sedative or hypnotic medications within 24 hours before colonoscopy. 8. History of seizure disorders or brain metastasis. 9. Chronic pain syndrome or regular opioid use. 10. Any condition considered by the investigator to make participation unsafe.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation quality During colonoscopy procedure Ramsay Sedation Score | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery time Post procedure recovery period Time to achieve Aldrete Recovery Score of 9 or higher,Hemodynamic stability Baseline and every 5 minutes during colonoscopy Mean arterial pressure, heart rate and oxygen saturation,Adverse events During procedure and recovery period Incidence of hypotension, desaturation, apnea, airway obstruction and emergence reactions,Patient satisfaction Sixty minutes after colonoscopy Three point satisfaction scale,Endoscopist satisfaction Immediately after colonoscopy Three point satisfaction scale | — |
Countries
Thailand
Contacts
Public ContactNutthineenart Tongdee
Sikhoraphum Hospital
Outcome results
None listed