Healthy population polynucleotide, microbiome, skin rejuvenation
Conditions
Interventions
20 mg/mL of polynucleotide intradermally injection, 0.05 mL per injection point using prefilled syringe and 33-gauze needle, 1 mL each anterior medial cheeks, total 2 mL
Experimental Procedure/Surgery
Polynucleotide injection
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
25 Years to 45 Years
Inclusion criteria
Inclusion criteria: Participants who are interested in skin rejuvenation
Exclusion criteria
Exclusion criteria: 1. Pregnancy, possibly pregnancy or lactating, 2. Known allergies to marine products or polynucleotides, neuromuscular disorders, immunosuppression, or any severe systemic illness, 3. Active skin infection or inflammation including severe acne, dermatitis, or rosacea on the face, 4. History of systemic antibiotics, antifungals, or steroids for at least 4 weeks prior to the study, 5. History of retinoids or antibiotics applied to the face at least 4 weeks prior to the study, 6. History of botulinum toxin injection or mesotherapy within 6 months on the measured area, 7. History of fillers, fat grafting, thread lifting, energy-based treatment within 6 months on the measured area?, 8. History of prebiotic or oral supplements at least 4 weeks priors to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alternation in skin microbiome diversity and composition At week 2, 4, 8, 12 Skin sample | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin pore At week 2, 4, 8 , 12 Antera 3D,Skin texture At week 2, 4, 8, 12 Antera 3D,Wrinkle At week 2, 4, 8, 12 Antera 3 D,Erythema At week 2, 4, 8, 12 Antera 3D,Pigment At week 2, 4, 8, 12 Antera 3D,Hydration At week 2, 4, 8, 12 Cutometer,Elasticity At week 2, 4, 8, 12 Cutometer,Transepidermal water loss At week 2, 4, 8, 12 Tewameter,Sebum level At week 2, 4, 8, 12 Sebumeter,Skin pH At week 2, 4, 8, 12 Skin pH-meter,Skin improvement evaluation At week 2, 4, 8, 12 Photo and evaluation surveys,Adverse events during the study Evaluation form | — |
Countries
Thailand
Contacts
Public ContactJitlada Meephansan
Chulabhorn International College of Medicine Thammasat University
Outcome results
None listed