Post-surgical wound erythema, pain, suture removal day and scar Topical 0.5% timolol maleate ophthalmic solution, Mohs surgery
Conditions
Interventions
Apply 1 drop of 0.5% timolol maleate ophthalmic solution per 2 cm of surgical wound length, apply immediately after surgery, on days 2, 4 or 5, 7, and 14
(In patients whose sutures are completely remo
Active Comparator Drug,Placebo Comparator Drug
Topical 0.5% timolol maleate ophthalmic solution,Standard wound care
Sponsors
Dermatology department, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older 2. Participants who are expected to be able to comply with the study protocol 3. Diagnosed with basal cell carcinoma, squamous cell carcinoma, or Bowen disease of the face, neck, scalp, or ears, and undergoing treatment with Mohs micrographic surgery 4. Postoperative wound size between 1 and 10 centimeters
Exclusion criteria
Exclusion criteria: 1. History of easily keloid scar formation 2. Taking immunosuppressive medications such as prednisolone, methotrexate, azathioprine, or rituximab 3. Has a blood clotting disorder 4. Has underlying medical conditions such as asthma, chronic obstructive pulmonary disease, second or third degree heart block, congestive heart failure, or stage 4 or 5 chronic kidney disease 5. Has underlying medical conditions that may affect wound healing, such as uncontrolled type 2 diabetes mellitus, systemic lupus erythematosus 6. Previous chemotherapy or radiation therapy to the facial area 7. Pregnancy or breastfeeding 8. Allergy to timolol 9. Has bradycardia 10. Has a neurological condition that impairs the ability to make a decision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postsurgical wound erythema Days 4 or 5, day 7, and day 14 Erythema index by Colorimeter Derma-spectrometer(DSM) III | — |
Secondary
| Measure | Time frame |
|---|---|
| Postsurgical wound erythema Days 4 or 5, day 7, and day 14 Clinician erythema assessment scale (CEA), Antera3D ,Postsurgical pain Days 2, day 4 or 5, day 7, and day 14 Visual analogue scale ,Re-epithelialization Day 7 or day 14 Suture removal day without wound dehiscence,Postsurgical scar Day 42 Patient and Observer Scar Assessment Scale (POSAS) | — |
Countries
Thailand
Contacts
Public ContactNatthachat Jurairattanaporn
Dermatology department, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed