Comparison of Myocardial Injury After Non-Cardiac Surgery Between Spinal and General Anesthesia in Patients Undergoing Total Knee Arthroplasty: A Prospective Randomized Controlled Trial

Comparison of Myocardial Injury After Non-Cardiac Surgery (MINS) Between Spinal and General Anesthesia in Patients Undergoing Total Knee Arthroplasty: A Prospective Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260629002

Enrollment

170

Registered

2026-06-29

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Injury After Non-Cardiac Surgery Knee Osteoarthritis Total Knee Arthroplasty Spinal Anesthesia General Anesthesia Troponin Myocardial Injury

Interventions

Patients in this group will receive standard spinal anesthesia for elective total knee arthroplasty.,Patients in this group will receive standard general anesthesia for elective total knee arthroplast

Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery

Spinal Anesthesia,General Anesthesia

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.) Patients aged between 50 and 75 years. 2.) Patients scheduled for elective total knee arthroplasty surgery.

Exclusion criteria

Exclusion criteria: 1.) History of ischemic heart disease. 2.) Presence of congestive heart failure. 3.) Severe hepatic impairment. 4.) Renal failure requiring dialysis.

Design outcomes

Primary

Measure	Time frame
Postoperative Troponin Levels Preoperative, Postoperative 24th hour Laboratory blood analysis of cardiac troponin levels to assess myocardial injury.	—

Secondary

Measure	Time frame
Hemoglobin (Hb) and Hematocrit (Htc) Levels Preoperative and Postoperative 24th hour. Laboratory complete blood count (CBC) analysis.,Blood Urea Nitrogen (BUN) and Creatinine Levels Preoperative and Postoperative 24th hour. Laboratory serum biochemical analysis.	—

Countries

Turkey

Contacts

Public ContactMuhammed Baspinar

Fethi Sekin City Hospital

bspnr.muhammed@gmail.com905395831141

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026