Skin barrier dysfunction in atopic dermatitis Ceramides, Dermatitis, Atopic Xerosis
Conditions
Interventions
Participants will apply the cream to the assigned side of the arm and leg for a duration of 4 weeks.
Experimental Device
Erbatop Advance Intensive Cream
Sponsors
BANGKOK BOTANICA CO.,LTD.
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged between 18 and 60 years. 2. Diagnosed with atopic dermatitis according to the Hanifin & Rajka criteria, with a disease severity classified as mild to moderate. 3. Able to read and understand the Thai language, and capable of completing the questionnaires.
Exclusion criteria
Exclusion criteria: 1. Individuals with a known history of allergy to Erbatop Advance Intensive Cream or any of its ingredients. 2. Individuals diagnosed with other skin conditions affecting the designated study areas, such as skin infections, photosensitive dermatoses, or psoriasis, with active flare-ups or exacerbations within 2 weeks prior to study enrollment. 3. Individuals who have taken oral/systemic corticosteroids, JAK inhibitors, or other immunosuppressive medications within 2 weeks prior to study enrollment. 4. Individuals who have used topical corticosteroids, topical calcineurin inhibitors, or crisaborole within 1 week prior to study enrollment. 5. Individuals who have used any other moisturizing products (creams or lotions) within 1 week prior to study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hydration level of the stratum corneum baseline, 15 minutes, 2 hours, 4 hours, 8 hours, 1 week, 4 week corneometer ,Trans-epidermal water loss baseline, 15 minutes, 2 hours, 4 hours, 8 hours, 1 week, 4 week Tewameter,Redness baseline, 15 minutes, 2 hours, 4 hours, 8 hours, 1 week, 4 week Colorimeter | — |
Secondary
| Measure | Time frame |
|---|---|
| Atopic Dermatitis Severity index baseline, 1 week, 4 week Physician,The overall skin dryness score baseline, 1 week, 4 week Physician,Specified symptom sun score system baseline, 1 week, 4 week Physician,Patients improvement baseline, 1 week, 4 week Quartile scale, Safety baseline, 1 week, 4 week adverse events | — |
Countries
Thailand
Contacts
Public ContactSupenya Varothai
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed