Effect of postbiotic toothpaste on oral health in periodontitis patients

Effect of toothpaste containing Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 postbiotics on oral health in periodontitis patients

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260624004

Enrollment

Registered

2026-06-24

Start date

2026-06-23

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis (Stage III &amp

Interventions

Arm 1 (Test Group) Postbiotic Toothpaste Participants will use postbiotic toothpaste containing heat-killed Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 combined with sodium

Active Comparator No treatment,Placebo Comparator No treatment

Postbiotic toothpaste containing Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 with sodium fluoride 1,500 ppm,Placebo toothpaste with sodium fluoride 1,500 ppm

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Thai participants aged 30 to 65 years 2. Newly diagnosed with Periodontitis Stage III or Stage IV (EFP/AAP Classification 2018) 3. No prior periodontal treatment (scaling and root planing) for at least 1 year

Exclusion criteria

Exclusion criteria: 1 History of antibiotic use within 12 weeks prior to enrollment 2 Regular use of postbiotic- or probiotic-containing toothpaste before enrollment 3 Known allergy to any ingredient in the test toothpaste 4 Risk of adverse reactions to postbiotics (e.g., prior allergy to postbiotic/probiotic products) 5 Pregnant patients 6 Patients with Diabetes Mellitus 7 Current smokers

Design outcomes

Primary

Measure	Time frame
Oral microbiome composition Salivary interleukin-8 level Porphyromonas gingivalis count Fusobacterium nucleatum countAggregatibacter actinomycetemcomitans countStreptococcus mutans count 4 week after intervention 16S ribosomal RNA gene sequencEnzyme-linked immunosorbent assaying Quantitative real-time polymerase chain reaction	—

Secondary

Measure	Time frame
Clinical attachment level Bleeding on probing Plaque index Root caries index 4 weeks after intervention Periodontal probe measurement in millimeters Dichotomous scoring using periodontal probe Silness and Loe Plaque Index Root Caries Index	—

Countries

Thailand

Contacts

Public ContactMutita Wongsuwanlert

Faculty of Dentistry, Prince of songkhla university

mutita.w@psu.ac.th074287571

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026