mild to severe melasma Melasma, Fitzpatrick skin types III to V, Hemifacial mMASI score
Conditions
Interventions
Applied twice daily (morning and evening) in a thin, even layer on the entire face. Approximately 0.5 grams of cream (equivalent to one fingertip) will be applied to the face in the morning and evenin
Experimental Drug,Experimental Drug
0.3% Melatonin cream ,3% Tranexamic acid
Sponsors
Mae Fah Luang University
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Adults aged 20 to 50 years with Fitzpatrick skin types III to V. 2.Diagnosed with mild to severe melasma using the Hemifacial mMASI score. 3.Subject will be provided with written and verbal informed consent. 4.Subject who is willing to follow through the instructions to be studied and is willing to do follow up visits
Exclusion criteria
Exclusion criteria: 1.Use of systemic or topical depigmenting agents within 4 weeks. 2.History of hypersensitivity to systemic or topical melatonin or tranexamic acid. 3.Subject is pregnant, lactating or willing to be pregnant during the study. 4.Subject who is taking combined oral contraceptives or vitamin A derivatives. 5.Subjects with occupations or lifestyles involving prolonged sun exposure. 6.Subject has any condition or pathology on the skin that might affect the study, e.g., dermitis or any infection on the skin. 7.Subject with photosensitive pathology, e.g. thyroid disease, diabetes mellitus, photosensitive dermatoses, any liver or kidney disease. 8.Subjects who are on hormone therapy. 9.Subject who is taking drug that can casue photosensitivity such as doxycycline or co-trimoxazole. 10.Subject who is unable to communicate with the researcher which may be due to language problems, any neurological or mental disease. 11.Subject who is unreliable for the study due to excessive alcohol intake or any drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of melasma 3 months from the start hemifacial mMASI score | — |
Secondary
| Measure | Time frame |
|---|---|
| reduction of melasma 3 months from the start Maxameter | — |
Countries
Thailand
Contacts
Public ContactZaw Latt Ye Naung
Mae Fah Luang University
Outcome results
None listed