Evaluating the ALLSCAR Model for Predicting In-Hospital Mortality in Patients with Severe Cutaneous Adverse Reactions (SCARs): An External Validation Study in Thailand

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260621006

Enrollment

100

Registered

2026-06-21

Start date

2022-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult patients more than 17 years diagnosed with SCARs at six participating university and tertiary-care hospitals in Thailand: King Chulalongkorn Memorial Hospital, Siriraj Hospital, Ramathibodi Hospital, Phramongkutklao Hospital, Thammasat University Hospital, and Maharaj Nakorn Chiang Mai Hospital. SCARs, ALLSCAR model, In-Hospital Mortality

Interventions

Adult patients more than 17 years diagnosed with SCARs at six participating university and tertiary-care hospitals in Thailand: King Chulalongkorn Memorial Hospital, Siriraj Hospital, Ramathibodi Hos

Health Services Research

ThaiSCARs cohort

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adult patients with age more than 18 years 2. Diagnosed with SCARs at six participating university and tertiary-care hospitals in Thailand: King Chulalongkorn Memorial Hospital, Siriraj Hospital, Ramathibodi Hospital, Phramongkutklao Hospital, Thammasat University Hospital, and Maharaj Nakorn Chiang Mai Hospital.

Exclusion criteria

Exclusion criteria: 1. Participant under 18 years of age 2. Participant not diagnosed with SCARs, or those treated at institutions outside of the six participating hospitals (King Chulalongkorn Memorial Hospital, Siriraj Hospital, Ramathibodi Hospital, Phramongkutklao Hospital, Thammasat University Hospital, and Maharaj Nakorn Chiang Mai Hospital) will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
accuracy of the ALLSCAR score in predicting in-hospital mortality among patients with severe cutaneous adverse drug reactions (SCARs) of varying clinical phenotypes in Thailand one-time analysis at the end of study AUROC, Hosmer-Lemeshow test, Calibration plot	—

Secondary

Measure	Time frame
clinical features and laboratory findings across different SCARs phenotypes. one-time analysis at the end of study Frequency and Percentage, Mean and SD, Median and IQR ,clinical features and laboratory findings across patients with different treatment outcomes. one-time analysis at the end of study Frequency and Percentage, Mean and SD, Median and IQR,predictive accuracy of the ALLSCAR score versus the Neutrophil-to-Lymphocyte Ratio (NLR) for in-hospital mortality across SCARs phenotypes. one-time analysis at the end of study AUROC/C-statistic, DeLong's test, Hosmer-Lemeshow test, Calibration plot,predictive accuracy of the ALLSCAR score versus the SCORTEN score for in-hospital mortality in patients with Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (SJS/TEN). one-time analysis at the end of study AUROC/C-statistic, DeLong's test, Hosmer-Lemeshow test, Calibration plot,predictive accuracy of the ALLSCAR score versus the ABCD-10 score for in-hospital mortality in patients with SJS/TEN. one-time analysis at the end of study AUROC/C-statistic, DeLong's test, Hosmer-Lemeshow test, Calibration plot	—

Measure

Time frame

clinical features and laboratory findings across different SCARs phenotypes. one-time analysis at the end of study Frequency and Percentage, Mean and SD, Median and IQR ,clinical features and laboratory findings across patients with different treatment outcomes. one-time analysis at the end of study Frequency and Percentage, Mean and SD, Median and IQR,predictive accuracy of the ALLSCAR score versus the Neutrophil-to-Lymphocyte Ratio (NLR) for in-hospital mortality across SCARs phenotypes. one-time analysis at the end of study AUROC/C-statistic, DeLong's test, Hosmer-Lemeshow test, Calibration plot,predictive accuracy of the ALLSCAR score versus the SCORTEN score for in-hospital mortality in patients with Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (SJS/TEN). one-time analysis at the end of study AUROC/C-statistic, DeLong's test, Hosmer-Lemeshow test, Calibration plot,predictive accuracy of the ALLSCAR score versus the ABCD-10 score for in-hospital mortality in patients with SJS/TEN. one-time analysis at the end of study AUROC/C-statistic, DeLong's test, Hosmer-Lemeshow test, Calibration plot

—

Countries

Thailand

Contacts

Public ContactPawinee Rerknimitr

Faculty of Medicine, Chulalongkorn University

pawinee.r@chula.ac.th6622564253

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026