The comparison of the effectiveness of intra-articular corticosteroid injection and hyaluronic-corticosteroid injections in the treatment of patients with severe knee osteoarthritis

The comparison of the effectiveness of intra-articular corticosteroid injection and hyaluronic-corticosteroid injections in the treatment of patients with severe knee osteoarthritis : A Single-blinded Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20260618005

Enrollment

Registered

2026-06-18

Start date

2026-06-07

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End-stage of knee osteoarthritis End-stage of osteoarthritis, not ready for surgery

Interventions

Triamcinolone acetonide 40 mg 1ml with 1percent lidocaine 2ml with NSS 3 ml ,Triamcinolone acetonide 40 mg 1ml with 1percent lidocaine 2ml with hyaluronic acid 3 ml

Active Comparator Drug,Experimental Drug

corticosteroid injection,corticosteroid plus hyaluronic acid injection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Thai patients with severe, unilateral or bilateral knee osteoarthritis Kellgren Lawrence grade 4 who have not yet undergone surgery, at Bhumibol Adulyadej Hospital, Royal Thai Army, during the years 2024 to 2027. 2. Patients who do not respond to conservative treatment, such as pain relievers, NSAIDs, or physical therapy, for at least 3 months. 3. Patients with severe knee pain requiring further treatment. Patients with bilateral knee osteoarthritis can participate, with the knee experiencing the most pain being selected for this study.

Exclusion criteria

Exclusion criteria: 1. Patients who are bedridden or unable to walk 2. Patients with a history of rheumatoid arthritis, gout, or other types of inflammatory arthropathy 3. Patients with knee instability or obvious knee deformity 4. Patients with heart disease, neurological, or psychiatric disease that is so severe as to affect clinical assessment during the study 5. Patients with wounds or infections in the knee area 6. Patients with a history of previous knee surgery (Orthopedic surgery) 7. Patients who received intra-articular injections within 6 months prior to the start of the study 8. Patients who are unable to cooperate with symptom monitoring

Design outcomes

Primary

Measure	Time frame
Function of knee at 6 months after end of the intervention WOMAC score	—

Secondary

Measure	Time frame
Pain at 6 months after end of the intervention VAS score	—

Countries

Thailand

Contacts

Public ContactJirantanin Thanopajaisittikul

Bhumibol adulyadej hospital

oatjiran01@gmail.com0656514987

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026