Vascular malformations Lymphatic malformations Venous malformations Klippel-Trenaunay syndrome Veno-lymphatic malformations Arteriovenous malformations Sirolimus Vascular Malformations Lymphatic Malformations Venous Malformations Pediatrics Quality of Life
Conditions
Interventions
Pediatric patients aged 1 day to 18 years with vascular and lymphatic malformations who received sirolimus treatment at King Chulalongkorn Memorial Hospital. Patients were enrolled in an ambidirection
Treatment
Pediatric Vascular and Lymphatic Malformations
Sponsors
Kuakul Kiatphirakul, MD
Eligibility
Sex/Gender
All
Age
1 Days to 18 Years
Inclusion criteria
Inclusion criteria: 1 Pediatric patients aged 1 day to 18 years who were treated at the inpatient and/or outpatient departments of King Chulalongkorn Memorial Hospital 2 Diagnosed with vascular and/or lymphatic malformations 3 Received sirolimus treatment for vascular and/or lymphatic malformations 4 Patients treated during the 10 year retrospective period prior to IRB approval and newly diagnosed patients enrolled prospectively following IRB approval during the study period
Exclusion criteria
Exclusion criteria: 1 Patients whose diagnosis of vascular and/or lymphatic malformations was subsequently revised to another diagnosis 2 Patients with incomplete clinical data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response rate 6 months Proportion of patients achieving complete response or partial response based on clinical assessment | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events 12 months Incidence and types of adverse events during sirolimus treatment,Quality of life 6 months Change in quality of life scores using InToDermQoL and CDLQI | — |
Countries
Thailand
Contacts
Public ContactKuakul kiatphirakul
Department of Pediatrics Faculty of Medicine Chulalongkorn University
Outcome results
None listed