Genetic evaluation of Plasmodium falciparum resurgence on the Thailand Myanmar border

Emergence of PFHRP2 deletion on the Thailand Myanmar border: a retrospective molecular surveillance and prospective clinic based diagnostic assessment

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260617003

Enrollment

700

Registered

2026-06-17

Start date

2025-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genomic changes in falciparum malaria including PFHRP2 deletion in Plasmodium falciparum and its impact on malaria rapid diagnostic test performance Plasmodium falciparum Malaria PFHRP2 deletion Malaria rapid diagnostic test Molecular surveillance Whole Genome Sequencing Kelch13 R561H Thailand Myanmar border

Interventions

Confirmed Plasmodium falciparum infections collected through routine surveillance and antimalarial resistance monitoring between 2010 and 2024.,Consecutive febrile patients with microscopy confirmed P

Diagnostic,Diagnostic

Archived Plasmodium falciparum surveillance samples 2010 to 2024,Prospective microscopy confirmed Plasmodium falciparum infections 2025 to 2026

Eligibility

Sex/Gender

All

Age

2 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with mRDT or microscopy confirmed falciparum malaria

Exclusion criteria

Exclusion criteria: Severe malaria

Design outcomes

Primary

Measure	Time frame
Prevalence of PFHRP2 deletion among Plasmodium falciparum isolates End of the sample collection period Proportion of isolates with confirmed PFHRP2 deletion determined by nested PCR and or whole genome sequencing	—

Secondary

Measure	Time frame
Prevalence of kelch13 R561H mutation among Plasmodium falciparum isolates End of the sample collection period Proportion of isolates carrying the kelch13 R561H mutation determined by PCR and or whole genome sequencing,Diagnostic sensitivity of malaria rapid diagnostic tests for Plasmodium falciparum infection At enrolment Sensitivity of individual rapid diagnostic test products compared with microscopy,Diagnostic specificity of malaria rapid diagnostic tests for Plasmodium falciparum infection At enrolment Specificity of individual rapid diagnostic test products compared with microscopy,Prevalence of PFHRP3 deletion At enrolment Proportion of isolates with confirmed PFHRP3 deletion determined by nested PCR	—

Measure

Time frame

Prevalence of kelch13 R561H mutation among Plasmodium falciparum isolates End of the sample collection period Proportion of isolates carrying the kelch13 R561H mutation determined by PCR and or whole genome sequencing,Diagnostic sensitivity of malaria rapid diagnostic tests for Plasmodium falciparum infection At enrolment Sensitivity of individual rapid diagnostic test products compared with microscopy,Diagnostic specificity of malaria rapid diagnostic tests for Plasmodium falciparum infection At enrolment Specificity of individual rapid diagnostic test products compared with microscopy,Prevalence of PFHRP3 deletion At enrolment Proportion of isolates with confirmed PFHRP3 deletion determined by nested PCR

—

Countries

Thailand

Contacts

Public ContactAung Pyae Phyo

Shoklo Malaria Research Unit

aungpyaephyo@tropmedres.ac0927127091

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026