Acute exacerbation of chronic obstructive pulmonary disease (COPD) and risk of early recurrent exacerbation following hospitalisation, with focus on respiratory muscle dysfunction and imbalance in inspiratory muscle recruitment assessed by ultrasound. COPD Exacerbation Thickening Fraction Parasternal intercostal muscle Ultrasound
Conditions
Interventions
Patients hospitalized with moderate to severe COPD exacerbation.
Diagnostic
Exacerbated COPD
Sponsors
Cho Kalaphruek Excellent Research Project for Medical Students
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 40 years or more, 2. Confirmed diagnosis of COPD defined by post bronchodilator FEV1/FVC less than 0.7 within the preceding 12 months, 3. Post-bronchodilator FEV1 30 to 80% predicted, 4. Hospitalized with moderate-to-severe COPD exacerbation
Exclusion criteria
Exclusion criteria: 1. Respiratory rate 30 breaths/min or more, 2. Oxygen saturation less than 92% while receiving at least 5 L/min oxygen via nasal cannula, 3. Hemodynamic instability, 4. Altered level of consciousness, 5. Requirement for non-invasive ventilation, high-flow oxygen therapy, or invasive mechanical ventilation, 6. History of cardiothoracic surgery, 7. Neuromuscular disease affecting the diaphragm or intercostal muscles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent moderate-to-severe exacerbation 90 days Medical records, Diaphragm and parasternal intercostal ultrasound | — |
Secondary
| Measure | Time frame |
|---|---|
| Dyspnea score 90 days CAT score, mMRC score,Peak expiratory flow rate 90 days Mini-Wright peak flow meter | — |
Countries
Thailand
Contacts
Public ContactItthiphat Arunsurat
Faculty of Medicine, Khon Kaen University
Outcome results
None listed