Active phase of first stage of labor in term pregnancy Paracetamol vs Pethidine
Conditions
Interventions
Paracetamol 1000 mg IV drip in 15 minutes,Pethidine 50 mg IV stat
Experimental Drug,Active Comparator Drug
Paracetamol,Pethidine
Sponsors
Phramongkutklao hospital
Eligibility
Sex/Gender
Female
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Pregnant women aged 20 years or older. 2. No contraindications for vaginal delivery. 3. Planned delivery at gestational age 37 weeks or greater. 4. Willing to participate in the study and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergy to paracetamol. 2. History of allergy to pethidine. 3. Presence of underlying medical conditions, including asthma, severe hepatic impairment, renal failure, heart disease, or G6PD deficiency. 4. History of substance abuse. 5. Presence of psychiatric disorders or inability to cooperate with pain assessment. 6. Indication for cesarean delivery. 7. Multiple pregnancy. 8. Fetus diagnosed with congenital anomalies that may impede vaginal delivery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score 0,30,60 minutes numeric rating scores | — |
Secondary
| Measure | Time frame |
|---|---|
| Dizziness 60 minutes Yes/No,APGAR 1-10 score,NICU 1 day Yes/No,neonatal death 1 day Yes/No,Nausea/Vomiting 60 minutes Yes/No,Respiratory Distress 60 minutes Yes/No | — |
Countries
Thailand
Contacts
Public ContactTatchamon Prasartintara
Phramongkutklao hospital
Outcome results
None listed