Fetal brain development during early pregnancy and its sonographic measurement in normal singleton pregnancies. fetal brain angle first-trimester ultrasound reference values gestational age trisomy 21
Conditions
Interventions
Participants are pregnant women with normal singleton pregnancies undergoing routine first trimester ultrasound examination between 11 and 13 weeks plus 6 days of gestation. The fetal brain angle is m
Other
Normal singleton pregnancies
Sponsors
Rajavithi hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Pregnant women with singleton pregnancies undergoing routine first trimester ultrasound examination at 11 to 13 weeks plus 6 days of gestation at Rajavithi Hospital. 2.Participants must have an adequate mid sagittal ultrasound image of the fetal head allowing measurement of the fetal brain angle.
Exclusion criteria
Exclusion criteria: 1.Pregnancies with fetal structural anomalies 2.Pregnancies with confirmed chromosomal abnormalities including trisomy 21 diagnosed prenatally or postnatally. 3.Pregnancies in which an adequate fetal brain angle measurement cannot be obtained
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fetal brain angle At 11 to 13 weeks plus 6 days of gestation during routine first trimester ultrasound examination Angle measurement in degrees obtained from the true mid sagittal ultrasound view of the fetal head during first trimester ultrasound examination | — |
Secondary
| Measure | Time frame |
|---|---|
| Factors associated with fetal brain angle At the time of first trimester ultrasound examination between 11 and 13 weeks plus 6 days of gestation Association between fetal brain angle and maternal and ultrasound parameters analyzed using linear regression | — |
Countries
Thailand
Contacts
Public ContactPongrit Anutariya
Rajavithi
Outcome results
None listed