Dry mouth, xerostomia, radiation induced xerostomia, saliva substitute Dry mouth, xerostomia, radiation induced xerostomia, saliva substitute, Ginger.
Conditions
Interventions
Ginger extract has shown promise in reducing xerostomia symptoms. The mechanism of action may involve ginger'
s parasympathetic activity and its anti-inflammatory properties. Additionally, ginger'
s bioactive compounds have been shown to reduce inflammation and promote vasodilation, which could contribute to improved salivary gland function,Saliva substitutes are designed to moisturize and lubr
Experimental Drug,Active Comparator Drug
Ginger saliva substitute,Standard CMC-based Saliva substitute
Sponsors
Thai Red Cross Society research funding
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 70 years and diagnosis of thyroid cancer or head and neck cancer 2. Experienced at least CTCAE grade II radiation-induced xerostomia 3. Must have all 4 xerostomia symptoms including the feeling of low amount of saliva, difficulty in swallowing food, feeling of dry mouth when eating and must sip water to help when swallowing dry food such as bread, toast, cracker or rice 4. Duration of symptoms at least 6 months prior to the study
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to any product ingredient 2. Inability of compliance to study protocol 3. Refusal to complete the consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score at 10 and 60 min dry mouth symptoms ,Salivary flow at 10 and 60 min Schirmer test | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfactory level after use Questionaires | — |
Countries
Thailand
Contacts
Public ContactKanaungnit Kingpetch
Chulalongkorn University
Outcome results
None listed